换一批
换一批The current agonists and positive allosteric modulators of <i>α</i>7 nAChR for CNS indications in clinical trials.
第一作者：
Taoyi,Yang
第一单位：
Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
作者：
关键词
5-CSRTT, five-choice serial reaction time task5-HT, serotoninACh, acetylcholineAD, Alzheimer's diseaseADHD, attention deficit hyperactivity disorderAcetylcholineAlpha7Alzheimer's diseaseAβ, amyloid-β peptideCNS, central nervous systemDMTS, delayed matching-to-sampleECD, extracellular domainGABA, γ-aminobutyric acidIon channelMLA, methyllycaconitineNOR, novel object recognitionPAMs, positive allosteric modulatorsPCP, neonatal phencyclidinePD, Parkinson's diseasePPI, prepulse inhibitionPositive allosteric modulatorsSAR, structure–activity relationshipSchizophreniaTMD, transmembrane domainsnAChRnAChR, nicotinic acetylcholine receptorα-Btx, α-bungarotoxin
DOI
10.1016/j.apsb.2017.09.001
PMID
29159020
发布时间
2020-09-29
- 浏览6
Acta pharmaceutica Sinica. B
2017年7卷6期
611-622页
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