Enrichment of colorectal cancer associations in functional regions: Insight for using epigenomics data in the analysis of whole genome sequence-imputed GWAS data.
作者:
Stephanie A,Bien [1]
;
Paul L,Auer [2]
;
Tabitha A,Harrison [1]
;
Conghui,Qu [1]
;
Charles M,Connolly [1]
;
Peyton G,Greenside [3]
;
Sai,Chen [4]
;
Sonja I,Berndt [5]
;
Stéphane,Bézieau [6]
;
Hyun M,Kang [4]
;
Jeroen,Huyghe [1]
;
Hermann,Brenner [7]
;
Graham,Casey [8]
;
Andrew T,Chan [9]
;
John L,Hopper [10]
;
Barbara L,Banbury [1]
;
Jenny,Chang-Claude [11]
;
Stephen J,Chanock [5]
;
Robert W,Haile [12]
;
Michael,Hoffmeister [13]
;
Christian,Fuchsberger [4]
;
Mark A,Jenkins [10]
;
Suzanne M,Leal [14]
;
Mathieu,Lemire [15]
;
Polly A,Newcomb [1]
;
Steven,Gallinger [16]
;
John D,Potter [1]
;
Robert E,Schoen [17]
;
Martha L,Slattery [18]
;
Joshua D,Smith [19]
;
Loic,Le Marchand [20]
;
Emily,White [21]
;
Brent W,Zanke [22]
;
Goncalo R,Abeçasis [4]
;
Christopher S,Carlson [21]
;
Ulrike,Peters [21]
;
Deborah A,Nickerson [19]
;
Anshul,Kundaje [23]
;
Li,Hsu [24]
;
GECCO and CCFR
作者单位:
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
[1]
Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, United States of America.
[2]
Biomedical Informatics Program, Stanford University, Stanford, California, United States of America.
[3]
Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
[4]
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
[5]
Service de Génétique Médicale, Centre Hospitalier Universitaire de Nantes, Nantes, France.
[6]
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.;Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.;German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
[7]
Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America.
[8]
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.;Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
[9]
Centre for Epidemiology and Biostatistics, Melbourne School of Population Health, The University of Melbourne, Melbourne, Victoria, Australia.
[10]
Division of Cancer Epidemiology C020, German Cancer Research Center (DKFZ), Heidelberg, Germany.;University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
[11]
Division of Medical Oncology, Stanford School of Medicine, Stanford, California, United States of America.
[12]
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[13]
Department of Molecular and Human Genetics, Baylor College of Medicine Center for Statistical Genetics, Houston, Texas, United States of America.
[14]
Ontario Institute for Cancer Research, MaRS Centre, South Tower, Toronto, Ontario, Canada.
[15]
Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada.
[16]
Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America.
[17]
Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America.
[18]
Department Genome Sciences, University of Washington, Seattle, Washington, United States of America.
[19]
University of Hawai'i Cancer Center, Honolulu, Hawai'i, United States of America.
[20]
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.;Department of Epidemiology, University of Washington, Seattle, Washington, United States of America.
[21]
Division of Hematology, University of Ottawa, Ottawa, Ontario, Canada.;Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
[22]
Department of Genetics, Stanford University, Stanford, California, United States of America.
[23]
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.;Department of Biostatistics, University of Washington, Seattle, Washington, United States of America.
[24]
主题词
结直肠肿瘤(Colorectal Neoplasms);表观基因组学(Epigenomics);基因频率(Gene Frequency);全基因组关联研究(Genome-Wide Association Study);基因组学(Genomics);人类(Humans);多态性, 单核苷酸(Polymorphism, Single Nucleotide);数量性状基因座位(Quantitative Trait Loci);调控序列, 核酸(Regulatory Sequences, Nucleic Acid)
DOI
10.1371/journal.pone.0186518
PMID
29161273
发布时间
2024-09-22
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PloS one
PloS one
e0186518页
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