换一批
换一批KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease.
第一作者：
Cinzia,Antognelli
第一单位：
Department of Experimental Medicine, University of Perugia, Italy. Electronic address: cinzia.antognelli@unipg.it.
作者：
关键词
Adaptive redox homeostasisAntioxidant defenseArgpyrimidine-modified heat-shock proteinsCCM1/KRIT1Cerebral Cavernous MalformationsCerebrovascular diseaseGlyoxalase 1 (Glo1)Heme oxygenase-1 (HO-1)Nuclear factor erythroid 2-related factor 2 (Nrf2)Oxidative DNA damage and apoptosisOxidative stressRedox signalingc-Jun
主题词
动物(Animals);细胞凋亡(Apoptosis);自噬(Autophagy);脑(Brain);细胞, 培养的(Cells, Cultured);中枢神经系统肿瘤(Central Nervous System Neoplasms);内皮细胞(Endothelial Cells);HSP27热休克蛋白质类(HSP27 Heat-Shock Proteins);HSP70热休克蛋白质类(HSP70 Heat-Shock Proteins);血管瘤, 海绵状, 中枢神经系统(Hemangioma, Cavernous, Central Nervous System);内环境稳定(Homeostasis);人类(Humans);乳酰谷胱甘肽裂合酶(Lactoylglutathione Lyase);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);突变(Mutation);NF-E2相关因子2(NF-E2-Related Factor 2);氧化还原(Oxidation-Reduction);氧化性应激(Oxidative Stress);蛋白质加工, 转译后(Protein Processing, Post-Translational);丙酮醛(Pyruvaldehyde)
DOI
10.1016/j.freeradbiomed.2017.11.014
PMID
29170092
发布时间
2024-03-13
- 浏览1
Free radical biology & medicine
202-218页
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