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Methylated flavonoids as anti-seizure agents: Naringenin 4',7-dimethyl ether attenuates epileptic seizures in zebrafish and mouse models.

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第一作者： Daniëlle,Copmans

第一单位： Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven - University of Leuven, Leuven, Belgium.

作者： Daniëlle,Copmans ^[1] ; Adriana M,Orellana-Paucar ^[2] ; Gert,Steurs ^[3] ; Yifan,Zhang ^[1] ; Annelii,Ny ^[1] ; Kenn,Foubert ^[4] ; Vasiliki,Exarchou ^[4] ; Aleksandra,Siekierska ^[1] ; Youngju,Kim ^[3] ; Wim,De Borggraeve ^[3] ; Wim,Dehaen ^[3] ; Luc,Pieters ^[4] ; Peter A M,de Witte ^[5]

作者单位： Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven - University of Leuven, Leuven, Belgium. ^[1] Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven - University of Leuven, Leuven, Belgium; Carrera de Bioquímica y Farmacia, Facultad de Ciencias Químicas, Universidad de Cuenca, Cuenca, Ecuador. ^[2] Molecular Design and Synthesis, Department of Chemistry, KU Leuven - University of Leuven, Leuven, Belgium. ^[3] Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium. ^[4] Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven - University of Leuven, Leuven, Belgium. Electronic address: peter.dewitte@kuleuven.be. ^[5]

关键词 Drug discovery Epilepsy Methylated flavonoids Mouse Naringenin Naringenin (PubChem CID: 932)Naringenin 4′,7-dimethyl ether (PubChem CID: 14057196)Naringenin 7-O-methyl ether (PubChem CID: 73571)Zebrafish kaempferide (PubChem CID: 5281666)kaempferol (PubChem CID: 5280863)