Hollow microneedle-mediated micro-injections of a liposomal HPV E7<sub>43-63</sub> synthetic long peptide vaccine for efficient induction of cytotoxic and T-helper responses.

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作者： Koen,van der Maaden ^[1] ; Jeroen,Heuts ^[2] ; Marcel,Camps ^[3] ; Maria,Pontier ^[4] ; Anton,Terwisscha van Scheltinga ^[5] ; Wim,Jiskoot ^[4] ; Ferry,Ossendorp ^[3] ; Joke,Bouwstra ^[4]

作者单位： Division of Drug Delivery Technology, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research (LACDR), Leiden University, 2300, RA, Leiden, The Netherlands. Electronic address: k.van.der.maaden@lacdr.leidenuniv.nl. ^[1] Division of Drug Delivery Technology, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research (LACDR), Leiden University, 2300, RA, Leiden, The Netherlands; Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, P.O. Box 9600, 2300 RC, Leiden, The Netherlands. ^[2] Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, P.O. Box 9600, 2300 RC, Leiden, The Netherlands. ^[3] Division of Drug Delivery Technology, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research (LACDR), Leiden University, 2300, RA, Leiden, The Netherlands. ^[4] Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, The Netherlands. ^[5]

关键词 Hollow microneedles Intradermal vaccination Liposomes Micro-injections Therapeutic cancer vaccine