The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting.

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第一作者： Dongming,Liang

第一单位： Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

作者： Dongming,Liang ^[1] ; Deirdre C,Tatomer ^[1] ; Zheng,Luo ^[2] ; Huang,Wu ^[3] ; Li,Yang ^[4] ; Ling-Ling,Chen ^[5] ; Sara,Cherry ^[6] ; Jeremy E,Wilusz ^[7]

作者单位： Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. ^[1] Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Science, Chinese Academy of Sciences, Shanghai 200031, China. ^[2] State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Science, Chinese Academy of Sciences, Shanghai 200031, China. ^[3] Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Science, Chinese Academy of Sciences, Shanghai 200031, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. ^[4] State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Science, Chinese Academy of Sciences, Shanghai 200031, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. ^[5] Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. ^[6] Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: wilusz@pennmedicine.upenn.edu. ^[7]

关键词 Laccase2 Pladienolide B SF3b1 backsplicing circRNA cleavage/polyadenylation exon definition pre-mRNA splicing spliceosome transcription termination