Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation.
作者:
Giovanni,Fiorito [1]
;
Silvia,Polidoro [2]
;
Pierre-Antoine,Dugué [1]
;
Mika,Kivimaki [3]
;
Erica,Ponzi [4]
;
Giuseppe,Matullo [5]
;
Simonetta,Guarrera [6]
;
Manuela B,Assumma [1]
;
Panagiotis,Georgiadis [2]
;
Soterios A,Kyrtopoulos [1]
;
Vittorio,Krogh [2]
;
Domenico,Palli [1]
;
Salvatore,Panico [2]
;
Carlotta,Sacerdote [7]
;
Rosario,Tumino [7]
;
Marc,Chadeau-Hyam [8]
;
Silvia,Stringhini [9]
;
Gianluca,Severi [10]
;
Allison M,Hodge [11]
;
Graham G,Giles [12]
;
Riccardo,Marioni [13]
;
Richard,Karlsson Linnér [14]
;
Aisling M,O'Halloran [1]
;
Rose A,Kenny [15]
;
Richard,Layte [3]
;
Laura,Baglietto [4]
;
Oliver,Robinson [3]
;
Cathal,McCrory [4]
;
Roger L,Milne [16]
;
Paolo,Vineis [17]
作者单位:
Italian Institute for Genomic Medicine (IIGM, former HuGeF), Via Nizza 52 -, 10126, Turin, Italy.
[1]
Department of Medical Sciences - University of Turin, C.So, Dogliotti, 14 - 10126, Italy.
[2]
Cancer Epidemiology & Intelligence Division, Cancer Council of Victoria, 615 St Kilda Road, Melbourne, Victoria, 3004, Australia.
[3]
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville Victoria, 3010, Australia.
[4]
Department of Epidemiology and Public Health - University College London, 1-19 Torrington Place, London, WC1E 6BT, United Kingdom.
[5]
Institute of Evolutionary Biology and Environmental Studies, University of Zürich, Winterthurerstrasse 190, Zürich, Switzerland.
[6]
Institute of Biology, Medicinal Chemistry, and Biotechnology, National Hellenic Research Foundation, Leof. Vasileos Konstantinou 48, Athens, 116 35, Greece.
[7]
Fondazione IRCCS - Istituto Nazionale dei Tumori, Via Venezian 1, 20133, Milan, Italy.
[8]
Istituto per lo Studio e la Prevenzione Oncologica (ISPO Toscana), Via Cosimo Il Vecchio, 2, 50139, Florence, Italy.
[9]
Department of Clinical Medicine and Surgery, University of Naples Federico II, Corso Umberto I, 40, 80138, Naples, Italy.
[10]
Piedmont Reference Centre for Epidemiology and Cancer Prevention (CPO Piemonte), Via Santena 7, 10126, Turin, Italy.
[11]
Cancer Registry and Histopathology Department, 'Civic - M. P. Arezzo' Hospital, ASP Ragusa, Piazza Igea, 1, 97100, Ragusa, Italy.
[12]
MRC-PHE Centre for Environment and Health, Imperial College London, St. Mary's Campus Paddington, W2 1PG, London, United Kingdom.
[13]
Institute of Social and Preventive Medicine Lausanne University Hospital (CHUV), Rue du Bugnon 46, 1011, Lausanne, Switzerland.
[14]
Inserm U1018, Center for Research in Epidemiology and Population Health (CESP), Gustave Roussy Institute, 114 rue Edouard Vaillant, 94805, Villejuif Cedex, France.
[15]
Centre for Genomic and Experimental Medicine - University of Edinburgh, Crewe Road, EH4 2XU, Edinburgh, United Kingdom.
[16]
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research (CNCR), Neuroscience Campus Amsterdam (NCA), VU University Amsterdam, De Boelelaan, 1085-1087 1081 HV, Amsterdam, The Netherlands.
[17]
Trinity College Dublin, Dublin, Ireland, UK.
[18]
Department of Clinical and Experimental Medicine, University of Pisa, Lungarno Antonio Pacinotti, 43, 56126, Pisa, Italy.
[19]
Italian Institute for Genomic Medicine (IIGM, former HuGeF), Via Nizza 52 -, 10126, Turin, Italy. p.vineis@imperial.ac.uk.
[20]
MRC-PHE Centre for Environment and Health, Imperial College London, St. Mary's Campus Paddington, W2 1PG, London, United Kingdom. p.vineis@imperial.ac.uk.
[21]
主题词
老年人(Aged);衰老(Aging);队列研究(Cohort Studies);DNA甲基化(DNA Methylation);后成说, 遗传(Epigenesis, Genetic);女(雌)性(Female);人类(Humans);男(雄)性(Male);中年人(Middle Aged);社会经济因素(Socioeconomic Factors)
DOI
10.1038/s41598-017-16391-5
PMID
29176660
发布时间
2022-03-30
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