Isolation of blood-brain barrier-crossing antibodies from a phage display library by competitive elution and their ability to penetrate the central nervous system.

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作者： George,Thom ^[1] ; Jon,Hatcher ^[2] ; Arron,Hearn ^[1] ; Judy,Paterson ^[1] ; Natalia,Rodrigo ^[1] ; Arthur,Beljean ^[1] ; Ian,Gurrell ^[2] ; Carl,Webster ^[1]

作者单位： a Antibody Discovery and Protein Engineering, MedImmune , Cambridge , UK. ^[1] b Neuroscience, IMED Biotech Unit, AstraZeneca , Cambridge , UK. ^[2]

关键词 Blood-Brain Barrier (BBB)FMAT IL1 receptor antagonist (IL-1RA)Pharmacokinetic (PK)bEND.3 mechanical hyperalgesic pain model

主题词动物(Animals);生物转运(Biological Transport);血脑屏障(Blood-Brain Barrier);内皮细胞(Endothelial Cells);女(雌)性(Female);人类(Humans);免疫轭合物(Immunoconjugates);白细胞介素1受体拮抗蛋白质(Interleukin 1 Receptor Antagonist Protein);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);神经痛(Neuralgia);大鼠(Rats);单链抗体(Single-Chain Antibodies);胞吞转运(Transcytosis)

DOI 10.1080/19420862.2017.1409320

PMID 29182455

发布时间 2019-01-18

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Isolation of blood-brain barrier-crossing antibodies from a phage display library by competitive elution and their ability to penetrate the central nervous system.

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Isolation of blood-brain barrier-crossing antibodies from a phage display library by competitive elution and their ability to penetrate the central nervous system.

mAbs

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mAbs

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