Macrophage enzyme and reduced inflammation drive brain correction of mucopolysaccharidosis IIIB by stem cell gene therapy.-论文-万方医学网

作者： Rebecca J,Holley ^[1] ; Stuart M,Ellison ^[1] ; Daniel,Fil ^[1] ; Claire,O'Leary ^[1] ; John,McDermott ^[1] ; Nishanthi,Senthivel ^[1] ; Alexander W W,Langford-Smith ^[1] ; Fiona L,Wilkinson ^[2] ; Zelpha,D'Souza ^[1] ; Helen,Parker ^[2] ; Aiyin,Liao ^[1] ; Samuel,Rowlston ^[1] ; Hélène F E,Gleitz ^[1] ; Shih-Hsin,Kan ^[1] ; Patricia I,Dickson ^[1] ; Brian W,Bigger ^[3]

作者单位： Stem Cell and Neurotherapies, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. ^[1] Vascular Pathology Group, Centre for Biomedicine, School of Healthcare Science, Faculty of Science and Engineering, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M1 5GD, UK. ^[2] Department of Paediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA, 90502, USA. ^[3]

主题词动物(Animals);脑(Brain);细胞因子类(Cytokines);疾病模型, 动物(Disease Models, Animal);脑炎(Encephalitis);女(雌)性(Female);神经胶质增生(Gliosis);葡糖氨基聚糖类(Glycosaminoglycans);人类(Humans);肝(Liver);巨噬细胞(Macrophages);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 转基因(Mice, Transgenic);黏多糖累积病Ⅲ型(Mucopolysaccharidosis III);泼尼松龙(Prednisolone);脾(Spleen);干细胞(Stem Cells);硫酸酯酶类(Sulfatases)

DOI 10.1093/brain/awx311

PMID 29186350

发布时间 2021-01-09

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Macrophage enzyme and reduced inflammation drive brain correction of mucopolysaccharidosis IIIB by stem cell gene therapy.

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Macrophage enzyme and reduced inflammation drive brain correction of mucopolysaccharidosis IIIB by stem cell gene therapy.

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