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Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer's Disease-like Pathology.

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第一作者： Jeffrey N,Savas

第一单位： Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: jeffrey.savas@northwestern.edu.

作者： Jeffrey N,Savas ^[1] ; Yi-Zhi,Wang ^[2] ; Laura A,DeNardo ^[3] ; Salvador,Martinez-Bartolome ^[4] ; Daniel B,McClatchy ^[4] ; Timothy J,Hark ^[2] ; Natalie F,Shanks ^[5] ; Kira A,Cozzolino ^[2] ; Mathieu,Lavallée-Adam ^[6] ; Samuel N,Smukowski ^[2] ; Sung Kyu,Park ^[4] ; Jeffery W,Kelly ^[4] ; Edward H,Koo ^[7] ; Terunaga,Nakagawa ^[5] ; Eliezer,Masliah ^[7] ; Anirvan,Ghosh ^[3] ; John R,Yates ^[8]

作者单位： Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: jeffrey.savas@northwestern.edu. ^[1] Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. ^[2] Neurobiology Section, Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA. ^[3] Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. ^[4] Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA. ^[5] Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Biochemistry, Microbiology and Immunology and Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1H 8M5, Canada. ^[6] Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA. ^[7] Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: jyates@scripps.edu. ^[8]

关键词 AD AMPAR ApoE WGCNA amyloid beta mass spectrometry proteomics proteostasis synapses

医学主题词阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);动物(Animals);载脂蛋白E类(Apolipoproteins E);脑(Brain);钙通道(Calcium Channels);计算生物学(Computational Biology);女(雌)性(Female);质谱分析法(Mass Spectrometry);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);蛋白质组(Proteome)

DOI 10.1016/j.celrep.2017.11.009

PMID 29186695

发布时间 2024-06-10

基金项目

P41 GM103533/GM/NIGMS NIH HHS/United States R01 MH067880/MH/NIMH NIH HHS/United States R01 AG017139/AG/NIA NIH HHS/United States R00 DC013805/DC/NIDCD NIH HHS/United States T32 AG020506/AG/NIA NIH HHS/United States P30 CA060553/CA/NCI NIH HHS/United States F32 AG039127/AG/NIA NIH HHS/United States K99 DC013805/DC/NIDCD NIH HHS/United States

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