Slowly Signaling G Protein-Biased CB<sub>2</sub> Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence.-论文-万方医学网

作者： Xiaoyan,Lin ^[1] ; Amey S,Dhopeshwarkar ^[1] ; Megan,Huibregtse ^[1] ; Ken,Mackie ^[1] ; Andrea G,Hohmann ^[2]

作者单位： Psychological and Brain Sciences (X.L., A.S.D., M.H., K.M., A.G.H.), Program in Neuroscience (K.M., A.G.H.), and Gill Center for Biomolecular Science (K.M., A.G.H.), Indiana University, Bloomington, Indiana. ^[1] Psychological and Brain Sciences (X.L., A.S.D., M.H., K.M., A.G.H.), Program in Neuroscience (K.M., A.G.H.), and Gill Center for Biomolecular Science (K.M., A.G.H.), Indiana University, Bloomington, Indiana hohmanna@indiana.edu. ^[2]

主题词镇痛药, 阿片类(Analgesics, Opioid);动物(Animals);抗肿瘤药(Antineoplastic Agents);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物耐受性(Drug Tolerance);GTP结合蛋白质类(GTP-Binding Proteins);HEK293细胞(HEK293 Cells);人类(Humans);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);吗啡(Morphine);吗啡依赖(Morphine Dependence);纳洛酮(Naloxone);麻醉品拮抗药(Narcotic Antagonists);神经痛(Neuralgia);紫杉酚(Paclitaxel);嘌呤类(Purines);受体, 大麻酚, CB2(Receptor, Cannabinoid, CB2);信号传导(Signal Transduction);物质戒断综合征(Substance Withdrawal Syndrome)

DOI 10.1124/mol.117.109355

PMID 29192123

发布时间 2025-02-13

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Slowly Signaling G Protein-Biased CB<sub>2</sub> Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence.

Molecular pharmacology

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Molecular pharmacology

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Slowly Signaling G Protein-Biased CB<sub>2</sub> Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence.

Molecular pharmacology

相似文献

Molecular pharmacology

相关期刊

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