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首页> Gene> Hypermethylation of PGCP gene is associated with human bronchial epithelial cells immortalization.

Hypermethylation of PGCP gene is associated with human bronchial epithelial cells immortalization.

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作者： Chen,Gao ^[1] ; Xiumei,Xing ^[1] ; Zhini,He ^[1] ; Shen,Chen ^[1] ; Shan,Wang ^[1] ; Qingye,Li ^[1] ; Ping,Guo ^[1] ; Haiyan,Zhang ^[1] ; Huiyao,Li ^[1] ; Liping,Chen ^[1] ; Qing,Wang ^[1] ; Jian,Zhao ^[2] ; Yongmei,Xiao ^[1] ; Wen,Chen ^[3] ; Daochuan,Li ^[4]

作者单位： Department of Toxicology, Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, School of Public Health, Sun Yat-sen University, Guangzhou, China. ^[1] Department of Chest Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China. ^[2] Department of Toxicology, Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, School of Public Health, Sun Yat-sen University, Guangzhou, China. Electronic address: chenwen@mail.sysu.edu.cn. ^[3] Department of Toxicology, Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, School of Public Health, Sun Yat-sen University, Guangzhou, China. Electronic address: lidchuan@mail.sysu.edu.cn. ^[4]

关键词 DNA methylome HBETT Immortalization Plasma glutamate carboxypeptidase (PGCP)Primary human bronchial epithelial cells (HPBECs)Transcriptome

主题词苯并芘(Benzo(a)pyrene);支气管(Bronchi);羧肽酶类(Carboxypeptidases);细胞系(Cell Line);细胞转化, 肿瘤(Cell Transformation, Neoplastic);CpG岛(CpG Islands);DNA甲基化(DNA Methylation);上皮细胞(Epithelial Cells);基因表达谱(Gene Expression Profiling);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);肺肿瘤(Lung Neoplasms);寡核苷酸序列分析(Oligonucleotide Array Sequence Analysis);启动区, 遗传(Promoter Regions, Genetic);信号传导(Signal Transduction)

DOI 10.1016/j.gene.2017.11.063

PMID 29196255

发布时间 2017-12-26

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