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DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation.

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作者单位: Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA. Electronic address: melissa.a.lee@uth.tmc.edu. [1] Population Sciences Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA; Framingham Heart Study, Framingham, MA 01702, USA. [2] Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000, the Netherlands. [3] Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA. [4] Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48108, USA. [5] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98195, USA. [6] Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. [7] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK; Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia. [8] Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City, UT 84108, USA. [9] Department of Twin Research and Genetic Epidemiology, Kings College London, SE17EH London, UK. [10] Division of Endocrinology, Diabetes, and Nutrition, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. [11] Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA. [12] Hospital for Sick Children, University of Toronto, Toronto, ON M5G 0A4, Canada. [13] Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. [14] Human Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA. [15] Department of Biostatistics, University of Minnesota, Minneapolis, MN 55454, USA. [16] Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA. [17] Human Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, TX 77030, USA. [18] Population Sciences Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA; Framingham Heart Study, Framingham, MA 01702, USA; Department of Biostatistics, Boston University, Boston, MA 02118, USA. [19] Population Sciences Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA; Framingham Heart Study, Framingham, MA 01702, USA; Department of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA. [20] Department of Internal Medicine, Erasmus University Medical Center, Rotterdam 3000, the Netherlands. [21] Department of Genetics, University of North Carolina, Chapel Hill, NC 27514, USA; Curriculum in Bioinformatics and Computational Biology, University of North Carolina, Chapel Hill, NC 27514, USA; Department of Statistics, University of North Carolina, Chapel Hill, NC 27514, USA. [22] Department of Genetics, University of North Carolina, Chapel Hill, NC 27514, USA; Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA. [23] Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA; Carolina Population Center, University of North Carolina, Chapel Hill, NC 27514, USA. [24] Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA 98101, USA; Kaiser Permanente Washington Health Research Unit, Seattle, WA 98101, USA. [25] Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA. [26] HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA. [27] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh EH8 9JZ, UK. [28] Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia. [29] Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. [30] Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. [31] Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. [32] Veterans Affairs Normative Aging Study, Veterans Affairs Boston Healthcare System, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA. [33] Division of Endocrinology, Diabetes, and Nutrition, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA; The Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA. [34] Department of Medicine, Columbia University, New York, NY 10032, USA. [35] Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. [36] Departments of Psychology and Psychiatry, University of Toronto, Toronto, ON M5S 3G3, Canada; Rotman Research Institute, Baycrest, Toronto, ON M6A 2E1, Canada; Child Mind Institute, New York, NY 10022, USA. [37] Department of Human Genetics, Gonda Research Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. [38] Hospital for Sick Children, University of Toronto, Toronto, ON M5G 0A4, Canada; Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada. [39] Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA 98195, USA. [40] University of Kentucky, College of Public Health, Lexington, KY 40563, USA. [41] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK; Department of Psychology, University of Edinburgh, Edinburgh EH9 8JZ, UK. [42] Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA. [43] Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000, the Netherlands; Department of Biostatistics and Epidemiology, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK. [44] Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA; Human Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, TX 77030, USA. Electronic address: myriam.fornage@uth.tmc.edu. [45]
DOI 10.1016/j.ajhg.2017.09.028
PMID 29198723
发布时间 2024-11-01
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American journal of human genetics

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