CD11c+ resident macrophages drive hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitis.

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作者： Michiko,Itoh ^[1] ; Takayoshi,Suganami ^[2] ; Hideaki,Kato ^[3] ; Sayaka,Kanai ^[2] ; Ibuki,Shirakawa ^[4] ; Takeru,Sakai ^[5] ; Toshihiro,Goto ^[1] ; Masahiro,Asakawa ^[2] ; Isao,Hidaka ^[2] ; Hiroshi,Sakugawa ^[2] ; Koji,Ohnishi ^[6] ; Yoshihiro,Komohara ^[7] ; Kenichi,Asano ^[8] ; Isao,Sakaida ^[8] ; Masato,Tanaka ^[9] ; Yoshihiro,Ogawa ^[6]

作者单位： Department of Organ Network and Metabolism and. ^[1] Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. ^[2] Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan. ^[3] Drug Discovery & Disease Research Laboratory, Shionogi & Co. Ltd., Osaka, Japan. ^[4] Department of Molecular and Cellular Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. ^[5] Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan. ^[6] Heart Life Hospital, Okinawa, Japan. ^[7] Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. ^[8] Laboratory of Immune regulation, School of Life Science, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan. ^[9] Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. ^[10] Japan Agency for Medical Research and Development, CREST, Tokyo, Japan. ^[11]

关键词 Fibrosis Hepatology Inflammation Macrophages Obesity

主题词动物(Animals);疾病模型, 动物(Disease Models, Animal);疾病恶化(Disease Progression);脂肪肝(Fatty Liver);肝细胞(Hepatocytes);人类(Humans);炎症(Inflammation);肝(Liver);肝硬化(Liver Cirrhosis);巨噬细胞(Macrophages);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);肥胖症(Obesity);受体, 黑皮质素, 4型(Receptor, Melanocortin, Type 4);受体, CCR2(Receptors, CCR2)

DOI 10.1172/jci.insight.92902

PMID 29202448

发布时间 2019-07-08

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CD11c+ resident macrophages drive hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitis.

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CD11c+ resident macrophages drive hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitis.

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