Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation.-论文-万方医学网

作者： Allyson M,Freedy ^[1] ; Maria J,Matos ^[1] ; Omar,Boutureira ^[1] ; Francisco,Corzana ^[1] ; Ana,Guerreiro ^[2] ; Padma,Akkapeddi ^[3] ; Víctor J,Somovilla ^[3] ; Tiago,Rodrigues ^[1] ; Karl,Nicholls ^[2] ; Bangwen,Xie ^[3] ; Gonzalo,Jiménez-Osés ^[4] ; Kevin M,Brindle ^[5] ; André A,Neves ^[2] ; Gonçalo J L,Bernardes ^[2]

作者单位： Department of Chemistry, University of Cambridge , Lensfield Road, CB2 1EW Cambridge, U.K. ^[1] Departamento de Química, Centro de Investigación en Síntesis Química, Universidad de La Rioja , 26006 Logroño, Spain. ^[2] Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa , Avenida Professor Egas Moniz, 1649-028 Lisboa, Portugal. ^[3] Albumedix Ltd., Castle Court , 59 Castle Boulevard, NG7 1FD Nottingham, U.K. ^[4] Li Ka Shing Centre, Cancer Research UK Cambridge Institute , Robinson Way, CB2 0RE Cambridge, U.K. ^[5]

主题词丙氨酸(Alanine);白蛋白类(Albumins);胺类(Amines);动物(Animals);膜联蛋白A5(Annexin A5);抗体(Antibodies);细胞死亡(Cell Death);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);二硫化物类(Disulfides);剂量效应关系, 药物(Dose-Response Relationship, Drug);HEK293细胞(HEK293 Cells);人类(Humans);动力学(Kinetics);小鼠(Mice);模型, 分子(Models, Molecular);分子结构(Molecular Structure);吡唑类(Pyrazoles);吡啶类(Pyridines);量子论(Quantum Theory);突触结合蛋白质Ⅰ(Synaptotagmin I)

DOI 10.1021/jacs.7b10702

PMID 29206031

发布时间 2024-02-10

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Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation.

Journal of the American Chemical Society

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Journal of the American Chemical Society

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Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation.

Journal of the American Chemical Society

相似文献

Journal of the American Chemical Society

相关期刊

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