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首页> Neurobiology of aging> Environmental enrichment improves hippocampal function in aged rats by enhancing learning and memory, LTP, and mGluR5-Homer1c activity.

Environmental enrichment improves hippocampal function in aged rats by enhancing learning and memory, LTP, and mGluR5-Homer1c activity.

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作者： Giuseppe P,Cortese ^[1] ; Andrew,Olin ^[2] ; Kenneth,O'Riordan ^[3] ; Rikki,Hullinger ^[4] ; Corinna,Burger ^[5]

作者单位： Department of Neurology, Medical Sciences Center, University of Wisconsin-Madison, Madison, WI, USA. ^[1] College of Letters and Science, University of Wisconsin-Madison, Madison, WI, USA. ^[2] Department of Pharmacology & Therapeutics, Trinity College, Dublin, Ireland. ^[3] Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI, USA. ^[4] Department of Neurology, Medical Sciences Center, University of Wisconsin-Madison, Madison, WI, USA; Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: burger@neurology.wisc.edu. ^[5]

关键词 Environmental enrichment Homer1c LTP Morris water maze Social enrichment mGluR p70S6 kinase

主题词衰老(Aging);动物(Animals);行为, 动物(Behavior, Animal);环境(Environment);海马(Hippocampus);动物房(Housing, Animal);学习(Learning);长时程增强(Long-Term Potentiation);男(雄)性(Male);迷宫学习(Maze Learning);记忆(Memory);大鼠, 近交F344(Rats, Inbred F344);受体, 亲代谢性谷氨酸盐(Receptors, Metabotropic Glutamate);核糖体蛋白质S6激酶类, 70-kDa(Ribosomal Protein S6 Kinases, 70-kDa);社会环境(Social Environment)

DOI 10.1016/j.neurobiolaging.2017.11.004

PMID 29207276

发布时间 2021-01-09

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