The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences.

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作者： Matilde,de Las Rivas ^[1] ; Erandi,Lira-Navarrete ^[1] ; Earnest James Paul,Daniel ^[2] ; Ismael,Compañón ^[3] ; Helena,Coelho ^[4] ; Ana,Diniz ^[5] ; Jesús,Jiménez-Barbero ^[6] ; Jesús M,Peregrina ^[7] ; Henrik,Clausen ^[5] ; Francisco,Corzana ^[6] ; Filipa,Marcelo ^[7] ; Gonzalo,Jiménez-Osés ^[8] ; Thomas A,Gerken ^[4] ; Ramon,Hurtado-Guerrero ^[2]

作者单位： BIFI, University of Zaragoza, BIFI-IQFR (CSIC) Joint Unit, Mariano Esquillor s/n, Campus Rio Ebro, Edificio I+D, Zaragoza, 50018, Spain. ^[1] Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, School of Dentistry, University of Copenhagen, Copenhagen, DK-2200, Denmark. ^[2] Department of Biochemistry, Case Western Reserve University, Cleveland, 44106, OH, USA. ^[3] Departamento de Química, Universidad de La Rioja, Centro de Investigación en Síntesis Química, E-26006, Logroño, Spain. ^[4] UCIBIO, REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade de Nova de Lisboa, Caparica, 2829-516, Portugal. ^[5] CIC bioGUNE, Bizkaia Technology Park, Building 801A, 48170, Derio, Spain. ^[6] Departament of Organic Chemistry II, Faculty of Science & Technology, University of the Basque Country, Leioa, Bizkaia, 48940, Spain. ^[7] Ikerbasque, Basque Foundation for Science, Maria Diaz de Haro 13, 48009, Bilbao, Spain. ^[8] Department of Pediatrics, Case Western Reserve University, Cleveland, 44106, OH, USA. ^[9] Department of Chemistry, Case Western Reserve University, Cleveland, 44106, OH, USA. ^[10] BIFI, University of Zaragoza, BIFI-IQFR (CSIC) Joint Unit, Mariano Esquillor s/n, Campus Rio Ebro, Edificio I+D, Zaragoza, 50018, Spain. rhurtado@bifi.es. ^[11] Fundación ARAID, 50018, Zaragoza, Spain. rhurtado@bifi.es. ^[12]