Lentiviral CRISPR/Cas9 nickase vector mediated BIRC5 editing inhibits epithelial to mesenchymal transition in ovarian cancer cells.

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作者： Guannan,Zhao ^[1] ; Qinghui,Wang ^[2] ; Qingqing,Gu ^[3] ; Wenan,Qiang ^[1] ; Jian-Jun,Wei ^[2] ; Peixin,Dong ^[4] ; Hidemichi,Watari ^[5] ; Wei,Li ^[4] ; Junming,Yue ^[6]

作者单位： Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, USA. ^[1] Center for Cancer Research, University of Tennessee Health Science Center, Memphis, USA. ^[2] Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, USA. ^[3] Department of Pathology, Department of Obstetrics and Gynecology, Northwestern University School of Medicine, Chicago, USA. ^[4] Center for Developmental Therapeutics, Chemistry of Life Processes Institute, Northwestern University, Evanston, USA. ^[5] Department of Women's Health Educational System, Hokkaido University School of Medicine, Hokkaido University, Sapporo, Japan. ^[6] Department of Gynecology, Hokkaido University School of Medicine, Hokkaido University, Sapporo, Japan. ^[7]

关键词 BIRC5 (survivin)CRISPR/Cas9 nickase epithelial to mesenchymal transition lentiviral vector ovarian cancer

DOI 10.18632/oncotarget.21863

PMID 29212257

发布时间 2019-11-20

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准确一般字义偏差语意偏离译文作用小提交