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Establishing and characterizing patient-derived xenografts using pre-chemotherapy percutaneous biopsy and post-chemotherapy surgical samples from a prospective neoadjuvant breast cancer study.

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第一作者： Jia,Yu

第一单位： Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

作者： Jia,Yu ^[1] ; Bo,Qin ^[2] ; Ann M,Moyer ^[3] ; Jason P,Sinnwell ^[4] ; Kevin J,Thompson ^[4] ; John A,Copland ^[5] ; Laura A,Marlow ^[5] ; James L,Miller ^[5] ; Ping,Yin ^[6] ; Bowen,Gao ^[7] ; Katherine,Minter-Dykhouse ^[6] ; Xiaojia,Tang ^[4] ; Sarah A,McLaughlin ^[8] ; Alvaro,Moreno-Aspitia ^[9] ; Anthony,Schweitzer ^[10] ; Yan,Lu ^[10] ; Jason,Hubbard ^[10] ; Donald W,Northfelt ^[11] ; Richard J,Gray ^[12] ; Katie,Hunt ^[13] ; Amy L,Conners ^[13] ; Vera J,Suman ^[4] ; Krishna R,Kalari ^[4] ; James N,Ingle ^[6] ; Zhenkun,Lou ^[6] ; Daniel W,Visscher ^[3] ; Richard,Weinshilboum ^[1] ; Judy C,Boughey ^[14] ; Matthew P,Goetz ^[2] ; Liewei,Wang ^[15]

作者单位： Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. ^[1] Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.;Department of Oncology, Mayo Clinic, Rochester, MN, 55905, USA. ^[2] Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA. ^[3] Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA. ^[4] Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, 32224, USA. ^[5] Department of Oncology, Mayo Clinic, Rochester, MN, 55905, USA. ^[6] Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. ^[7] Department of Surgery, Mayo Clinic, Jacksonville, FL, 32224, USA. ^[8] Department of Hematology/Oncology, Mayo Clinic, Jacksonville, FL, 32224, USA. ^[9] Affymetrix, now part of Thermo Fisher Scientific, Santa Clara, CA, 95051, USA. ^[10] Department of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ, 85259, USA. ^[11] Department of Surgery, Mayo Clinic, Scottsdale, AZ, 85259, USA. ^[12] Department of Radiology, Mayo Clinic, Rochester, MN, 55905, USA. ^[13] Department of Surgery, Mayo Clinic, Rochester, MN, 55905, USA. ^[14] Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Wang.Liewei@mayo.edu. ^[15]

关键词 Breast cancer Patient-derived Xenograft (PDX)Percutaneous tumor biopsies (PTB)Pre-clinical therapy Prospective neoadjuvant chemotherapy (NAC)