A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival.-论文-万方医学网

作者： Yiwen,Bu ^[1] ; Akihiro,Yoshida ^[1] ; Nilesh,Chitnis ^[1] ; Brian J,Altman ^[2] ; Feven,Tameire ^[3] ; Amanda,Oran ^[4] ; Victoria,Gennaro ^[4] ; Kent E,Armeson ^[5] ; Steven B,McMahon ^[4] ; Gerald B,Wertheim ^[6] ; Chi V,Dang ^[2] ; Davide,Ruggero ^[7] ; Constantinos,Koumenis ^[3] ; Serge Y,Fuchs ^[8] ; J Alan,Diehl ^[9]

作者单位： Department of Biochemistry and Molecular Biology and Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA. ^[1] Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA. ^[2] Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[3] Department of Cancer Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA. ^[4] Department of Public Health Sciences and Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA. ^[5] Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA. ^[6] Departments of Urology and Cellular and Molecular Pharmacology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA. ^[7] Department of Biomedical Sciences, School of Veterinary Medicine, Philadelphia, PA, USA. ^[8] Department of Biochemistry and Molecular Biology and Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA. diehl@musc.edu. ^[9]

主题词 ARNTL转录因子类(ARNTL Transcription Factors);动物(Animals);B-淋巴细胞(B-Lymphocytes);骨肿瘤(Bone Neoplasms);时钟蛋白质类(CLOCK Proteins);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);昼夜节律钟(Circadian Clocks);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);光信号传导(Light Signal Transduction);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 转基因(Mice, Transgenic);微RNAs(MicroRNAs);成骨细胞(Osteoblasts);骨肉瘤(Osteosarcoma);光照期(Photoperiod);RNA, 小分子干扰(RNA, Small Interfering);非折叠蛋白质应答(Unfolded Protein Response);eIF-2激酶(eIF-2 Kinase)

DOI 10.1038/s41556-017-0006-y

PMID 29230015

发布时间 2023-12-13

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A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival.

Nature cell biology

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A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival.

Nature cell biology

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Nature cell biology

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