Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity.

导出原文传递

翻译打印收藏纠错

作者： Hua,Gong ^[1] ; David S,Weinstein ^[1] ; Zhonghui,Lu ^[1] ; James J-W,Duan ^[1] ; Sylwia,Stachura ^[1] ; Lauren,Haque ^[1] ; Ananta,Karmakar ^[2] ; Hemalatha,Hemagiri ^[2] ; Dhanya Kumar,Raut ^[2] ; Arun Kumar,Gupta ^[2] ; Javed,Khan ^[1] ; Dan,Camac ^[1] ; John S,Sack ^[1] ; Andrew,Pudzianowski ^[1] ; Dauh-Rurng,Wu ^[1] ; Melissa,Yarde ^[1] ; Ding-Ren,Shen ^[1] ; Virna,Borowski ^[1] ; Jenny H,Xie ^[1] ; Huadong,Sun ^[1] ; Celia,D'Arienzo ^[1] ; Marta,Dabros ^[1] ; Michael A,Galella ^[1] ; Faye,Wang ^[1] ; Carolyn A,Weigelt ^[1] ; Qihong,Zhao ^[1] ; William,Foster ^[1] ; John E,Somerville ^[1] ; Luisa M,Salter-Cid ^[1] ; Joel C,Barrish ^[1] ; Percy H,Carter ^[1] ; T G Murali,Dhar ^[3]

作者单位： Bristol-Myers Squibb, Research and Development, Princeton, NJ 08543-4000, United States. ^[1] Bristol-Myers Squibb-Biocon Research Center, Bangalore, India. ^[2] Bristol-Myers Squibb, Research and Development, Princeton, NJ 08543-4000, United States. Electronic address: murali.dhar@bms.com. ^[3]