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Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasia.

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第一作者： Catherine E,Bond

第一单位： a QIMR Berghofer Medical Research Institute , Brisbane , Australia.

作者： Catherine E,Bond ^[1] ; Cheng,Liu ^[2] ; Futoshi,Kawamata ^[3] ; Diane M,McKeone ^[1] ; Winnie,Fernando ^[1] ; Saara,Jamieson ^[1] ; Sally-Ann,Pearson ^[1] ; Alexandra,Kane ^[1] ; Susan L,Woods ^[4] ; Tamsin R M,Lannagan ^[4] ; Roshini,Somashekar ^[4] ; Young,Lee ^[4] ; Troy,Dumenil ^[1] ; Gunter,Hartel ^[1] ; Kevin J,Spring ^[4] ; Jennifer,Borowsky ^[1] ; Lochlan,Fennell ^[1] ; Mark,Bettington ^[5] ; Jason,Lee ^[1] ; Daniel L,Worthley ^[6] ; Barbara A,Leggett ^[7] ; Vicki L J,Whitehall ^[8]

作者单位： a QIMR Berghofer Medical Research Institute , Brisbane , Australia. ^[1] a QIMR Berghofer Medical Research Institute , Brisbane , Australia.;b Envoi Specialist Pathologists , Brisbane , Australia.;c The University of Queensland , Brisbane , Australia. ^[2] a QIMR Berghofer Medical Research Institute , Brisbane , Australia.;d Hokkaido University Graduate School of Medicine , Sapporo , Japan. ^[3] e The University of Western Sydney , Australia. ^[4] a QIMR Berghofer Medical Research Institute , Brisbane , Australia.;b Envoi Specialist Pathologists , Brisbane , Australia. ^[5] f South Australia Health and Medical Research Institute , Adelaide , Australia.;g University of Adelaide , Adelaide , Australia. ^[6] a QIMR Berghofer Medical Research Institute , Brisbane , Australia.;c The University of Queensland , Brisbane , Australia.;h The Royal Brisbane and Women's Hospital , Brisbane , Australia. ^[7] a QIMR Berghofer Medical Research Institute , Brisbane , Australia.;c The University of Queensland , Brisbane , Australia.;i Pathology Queensland , Brisbane , Australia. ^[8]

关键词 BRAF DNA methylation cancer biology colorectal cancer methylation murine model serrated neoplasia