The dialkyl resorcinol stemphol disrupts calcium homeostasis to trigger programmed immunogenic necrosis in cancer.

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第一作者： Seungwon,Ji

第一单位： Department of Pharmacy, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08626, South Korea.

作者： Seungwon,Ji ^[1] ; Jin-Young,Lee ^[1] ; Jan,Schrör ^[2] ; Aloran,Mazumder ^[1] ; Dong Man,Jang ^[1] ; Sébastien,Chateauvieux ^[3] ; Michael,Schnekenburger ^[3] ; Che Ry,Hong ^[4] ; Christo,Christov ^[5] ; Hyoung Jin,Kang ^[4] ; Youngjo,Lee ^[6] ; Byung Woo,Han ^[1] ; Kyu-Won,Kim ^[7] ; Hee-Young,Shin ^[4] ; Mario,Dicato ^[8] ; Claudia,Cerella ^[3] ; Gabriele M,König ^[2] ; Barbora,Orlikova ^[3] ; Marc,Diederich ^[9]

作者单位： Department of Pharmacy, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08626, South Korea. ^[1] Institute of Pharmaceutical Biology University of Bonn, Nussallee 6, D 53115, Bonn, Germany. ^[2] Department of Pharmacy, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08626, South Korea; Laboratoire de Biologie Moléculaire du Cancer, Hôpital Kirchberg, 9, Rue Edward Steichen, L-2540, Luxembourg. ^[3] Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul National University Children's Hospital, Seoul, South Korea. ^[4] Faculté de Médecine, Université de Lorraine, Nancy, France. ^[5] Department of Statistics, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08626, South Korea. ^[6] SNU-Harvard Neurovascular Protection Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, South Korea. ^[7] Laboratoire de Biologie Moléculaire du Cancer, Hôpital Kirchberg, 9, Rue Edward Steichen, L-2540, Luxembourg. ^[8] Department of Pharmacy, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08626, South Korea. Electronic address: marcdiederich@snu.ac.kr. ^[9]

关键词 Calcium Cancer Caspase-independent apoptosis Leukemia Programmed necrosis