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Free-living human cells reconfigure their chromosomes in the evolution back to uni-cellularity.

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第一作者： Jin,Xu

第一单位： Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.

作者： Jin,Xu ^[1] ; Xinxin,Peng ^[1] ; Yuxin,Chen ^[2] ; Yuezheng,Zhang ^[1] ; Qin,Ma ^[3] ; Liang,Liang ^[3] ; Ava C,Carter ^[4] ; Xuemei,Lu ^[5] ; Chung-I,Wu ^[6]

作者单位： Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China. ^[1] State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China. ^[2] Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.;University of Chinese Academy of Sciences, Beijing, China. ^[3] Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, United States. ^[4] Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.;University of Chinese Academy of Sciences, Beijing, China.;CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, China. ^[5] Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.;State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.;Department of Ecology and Evolution, University of Chicago, Chicago, United States. ^[6]

关键词 cancer cell line dosage compensation evolutionary biology genomics multi-cellularity none sex chromsome evolution uni-cellularity

医学主题词适应, 生物学(Adaptation, Biological);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);染色体, 人(Chromosomes, Human);进化, 分子(Evolution, Molecular);人类(Humans);性染色体(Sex Chromosomes)

DOI 10.7554/eLife.28070

PMID 29251591

发布时间 2018-11-13

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准确一般字义偏差语意偏离译文作用小提交