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首页> Toxicology> Cadmium induced ROS alters M1 and M3 receptors, leading to SN56 cholinergic neuronal loss, through AChE variants disruption.

Cadmium induced ROS alters M1 and M3 receptors, leading to SN56 cholinergic neuronal loss, through AChE variants disruption.

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第一作者： Paula,Moyano

第一单位： Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain.

作者： Paula,Moyano ^[1] ; Mariano,de Frias ^[1] ; Margarita,Lobo ^[2] ; María José,Anadon ^[1] ; Emma,Sola ^[3] ; Adela,Pelayo ^[3] ; María Jesús,Díaz ^[2] ; María Teresa,Frejo ^[2] ; Javier,Del Pino ^[4]

作者单位： Department of Toxicology and Legal Medicine, Medical School, Complutense University of Madrid, 28041 Madrid, Spain. ^[1] Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain. ^[2] Department of Pathological Anatomy, Medical School, Complutense University of Madrid, 28041 Madrid, Spain. ^[3] Department of Toxicology and Pharmacology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain. Electronic address: jdelpino@pdi.ucm.es. ^[4]

关键词 AChE-R AChE-S Cadmium neurotoxicity Muscarinic receptor M1 Muscarinic receptor M3 SN56 basal forebrain cholinergic neurons

主题词乙酰胆碱酯酶(Acetylcholinesterase);动物(Animals);氯化镉(Cadmium Chloride);细胞系(Cell Line);细胞存活(Cell Survival);脂质过氧化作用(Lipid Peroxidation);记忆(Memory);小鼠(Mice);神经变性疾病(Neurodegenerative Diseases);氧化性应激(Oxidative Stress);前脑(Prosencephalon);活性氧(Reactive Oxygen Species);受体, 毒蕈碱M1(Receptor, Muscarinic M1);受体, 毒蕈碱M2(Receptor, Muscarinic M2)

DOI 10.1016/j.tox.2017.12.006

PMID 29253600

发布时间 2018-10-19

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