Atg5 Disassociates the V<sub>1</sub>V<sub>0</sub>-ATPase to Promote Exosome Production and Tumor Metastasis Independent of Canonical Macroautophagy.

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第一作者： Huishan,Guo

第一单位： Department of Cellular and Molecular Medicine, University of Ottawa, 3131 Roger Guindon Hall, 451 Smyth Road, Ottawa K1H 8M5, Canada.

作者： Huishan,Guo ^[1] ; Maneka,Chitiprolu ^[1] ; Luc,Roncevic ^[1] ; Charlotte,Javalet ^[2] ; Fiona J,Hemming ^[2] ; My Tran,Trung ^[1] ; Lingrui,Meng ^[1] ; Elyse,Latreille ^[1] ; Christiano,Tanese de Souza ^[3] ; Danielle,McCulloch ^[1] ; R Mitchell,Baldwin ^[1] ; Rebecca,Auer ^[3] ; Jocelyn,Côté ^[1] ; Ryan Charles,Russell ^[1] ; Rémy,Sadoul ^[2] ; Derrick,Gibbings ^[4]

作者单位： Department of Cellular and Molecular Medicine, University of Ottawa, 3131 Roger Guindon Hall, 451 Smyth Road, Ottawa K1H 8M5, Canada. ^[1] Institut National de la Santé et de la Recherche Médicale (INSERM), U1216, 38042 Grenoble, France; Université Grenoble Alpes, Institut des Neurosciences, 38042 Grenoble, France. ^[2] Ottawa Hospital Research Institute, Ottawa K1H 8L6, Canada. ^[3] Department of Cellular and Molecular Medicine, University of Ottawa, 3131 Roger Guindon Hall, 451 Smyth Road, Ottawa K1H 8M5, Canada; Ottawa Institute for System Biology, University of Ottawa, Ottawa K1H 8M5, Canada. Electronic address: gibbings@uottawa.ca. ^[4]

关键词 LC3 V(1)V(0)-ATPase acidification autophagy cancer endosome exosomes extracellular vesicles multivesicular body tumor