A new piperazine derivative: 1-(4-(3,5-di-tert-butyl-4-hydroxybenzyl) piperazin-1-yl)-2-methoxyethan-1-one with antioxidant and central activity.

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第一作者： Adriane F,Brito

第一单位： Post Graduate Program in Biological Sciences, ICB, Federal University of Goiás, Campus Samambaia, Goiania, GO, 74001-970, Brazil.

作者： Adriane F,Brito ^[1] ; Patrícia C C S,Braga ^[2] ; Lorrane K S,Moreira ^[1] ; Dayane M,Silva ^[1] ; Daiany P B,Silva ^[1] ; Germán,Sanz ^[3] ; Boniek G,Vaz ^[3] ; Flávio S,de Carvalho ^[3] ; Luciano M,Lião ^[3] ; Rafaela R,Silva ^[4] ; François,Noël ^[4] ; Hiasmin F S,Neri ^[1] ; Paulo C,Ghedini ^[1] ; Murilo F,de Carvalho ^[2] ; Eric,de S Gil ^[2] ; Elson A,Costa ^[5] ; Ricardo,Menegatti ^[2]

作者单位： Post Graduate Program in Biological Sciences, ICB, Federal University of Goiás, Campus Samambaia, Goiania, GO, 74001-970, Brazil. ^[1] Faculty of Pharmacy, Laboratory of Medicinal Pharmaceutical Chemistry, Federal University of Goiás, Goiania, GO, Brazil. ^[2] Chemistry Institute, Federal University of Goiás, Campus Samambaia, Goiania, GO, Brazil. ^[3] Laboratory of Biochemical and Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. ^[4] Department of Pharmacology, ICB, Federal University of Goiás, Campus Samambaia, 314, Goiania, GO, 74001-970, Brazil. xico@ufg.br. ^[5]

关键词 5-HT pathway Adrenergic pathway Antidepressant-like activity Anxiolytic-like activity Dopaminergic pathway Drug candidate