Discovery of orally efficacious RORγt inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds.

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第一作者： Junya,Shirai

第一单位： Pharmaceutical Research Division, Takeda Pharmaceutical Co., Ltd., Shonan Research Center, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan. Electronic address: junya.shirai@cardurion.com.

作者： Junya,Shirai ^[1] ; Yoshihide,Tomata ^[2] ; Mitsunori,Kono ^[2] ; Atsuko,Ochida ^[2] ; Yoshiyuki,Fukase ^[2] ; Ayumu,Sato ^[2] ; Shinichi,Masada ^[2] ; Tetsuji,Kawamoto ^[2] ; Kazuko,Yonemori ^[2] ; Ryoukichi,Koyama ^[2] ; Hideyuki,Nakagawa ^[2] ; Masaharu,Nakayama ^[2] ; Keiko,Uga ^[2] ; Akira,Shibata ^[2] ; Keiko,Koga ^[2] ; Toshitake,Okui ^[2] ; Mikio,Shirasaki ^[2] ; Robert,Skene ^[3] ; BiChing,Sang ^[3] ; Isaac,Hoffman ^[3] ; Wes,Lane ^[3] ; Yasushi,Fujitani ^[2] ; Masashi,Yamasaki ^[2] ; Satoshi,Yamamoto ^[2]

作者单位： Pharmaceutical Research Division, Takeda Pharmaceutical Co., Ltd., Shonan Research Center, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan. Electronic address: junya.shirai@cardurion.com. ^[1] Pharmaceutical Research Division, Takeda Pharmaceutical Co., Ltd., Shonan Research Center, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan. ^[2] Takeda California, 10410 Science Center Drive, San Diego, CA 92121, United States. ^[3]

关键词 Autoimmune disease IL-17 Inverse agonist Phenylglycinamide Retinoic acid receptor-related orphan receptor-gamma t (RORγt)Th17