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首页> Stroke> Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat.

Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat.

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作者： Keren,Zhou ^[1] ; Budbazar,Enkhjargal ^[1] ; Zhiyi,Xie ^[1] ; Chengmei,Sun ^[1] ; Lingyun,Wu ^[1] ; Jay,Malaguit ^[1] ; Sheng,Chen ^[1] ; Jiping,Tang ^[1] ; Jianmin,Zhang ^[2] ; John H,Zhang ^[2]

作者单位： From the Department of Neurosurgery, Second Affiliated Hospital, School of Medicine (K.Z., S.C., J.Z.), Brain research institute (K.Z., S.C., J.Z.), and Collaborative Innovation Center for Brain Science (K.Z., S.C., J.Z.), Zhejiang University, Hangzhou, China; and Department of Physiology and Pharmacology, Loma Linda University, CA (K.Z., B.E., Z.X.,C.S., L.W., J.M., J.T., J.H.Z.). ^[1] From the Department of Neurosurgery, Second Affiliated Hospital, School of Medicine (K.Z., S.C., J.Z.), Brain research institute (K.Z., S.C., J.Z.), and Collaborative Innovation Center for Brain Science (K.Z., S.C., J.Z.), Zhejiang University, Hangzhou, China; and Department of Physiology and Pharmacology, Loma Linda University, CA (K.Z., B.E., Z.X.,C.S., L.W., J.M., J.T., J.H.Z.). johnzhang3910@yahoo.com zjm135@zju.edu.cn. ^[2]

关键词 calcium-calmodulin-dependent protein kinase type 2 dihydrolipoic acid inflammasomes lysosomal-associated membrane protein 1 subarachnoid hemorrhage

主题词动物(Animals);钙-钙调素依赖性蛋白激酶2型(Calcium-Calmodulin-Dependent Protein Kinase Type 2);溶酶体(Lysosomes);MAP激酶激酶激酶类(MAP Kinase Kinase Kinases);MAP激酶信号系统(MAP Kinase Signaling System);男(雄)性(Male);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);蛛网膜下腔出血(Subarachnoid Hemorrhage);硫辛酸(Thioctic Acid)

DOI 10.1161/STROKEAHA.117.018593

PMID 29273596

发布时间 2023-12-13

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