Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts.

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作者： Laziyan,Mahemuti ^[1] ; Qixuan,Chen ^[2] ; Melanie C,Coughlan ^[3] ; Cunye,Qiao ^[1] ; Nikolai L,Chepelev ^[4] ; Maria,Florian ^[2] ; Dillon,Dong ^[5] ; Robert G,Woodworth ^[1] ; Jin,Yan ^[2] ; Xu-Liang,Cao ^[1] ; Kylie A,Scoggan ^[1] ; Xiaolei,Jin ^[1] ; William G,Willmore ^[6]

作者单位： Regulatory Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, HPFB, Health Canada, PL2202D, 251 Sir Frederick Banting Drive Way, Ottawa, ON, K1A 0K9, Canada. ^[1] Departments of Biology and Chemistry, Institute of Biochemistry, Carleton University, Ottawa, ON, Canada. ^[2] Nutrition Research Division, Bureau of Nutrition Sciences, Food Directorate, HPFB, Health Canada, Ottawa, ON, Canada. ^[3] Biostatistics and Modeling Division, Bureau of Food Surveillance and Science Integration, Food Directorate, HPFB, Health Canada, Ottawa, ON, Canada. ^[4] Mechanistic Studies Division, Environmental Health Science and Research Bureau, Environmental and Radiation Health Sciences Directorate, HECSB, Health Canada, Ottawa, ON, Canada. ^[5] Food Research Division, Bureau of Chemical Safety, Food Directorate, HPFB, Health Canada, Ottawa, ON, Canada. ^[6] Sector Strategies Division, Risk Management Bureau, Safe Environments Directorate, HECSB, Health Canada, Ottawa, ON, Canada. ^[7] Regulatory Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, HPFB, Health Canada, PL2202D, 251 Sir Frederick Banting Drive Way, Ottawa, ON, K1A 0K9, Canada. Dawn.Jin@canada.ca. ^[8]