Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model.

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作者： Arianne,van Koppen ^[1] ; Lars,Verschuren ^[2] ; Anita M,van den Hoek ^[3] ; Joanne,Verheij ^[1] ; Martine C,Morrison ^[4] ; Kelvin,Li ^[1] ; Hiroshi,Nagabukuro ^[5] ; Adalberto,Costessi ^[6] ; Martien P M,Caspers ^[7] ; Tim J,van den Broek ^[3] ; John,Sagartz ^[3] ; Cornelis,Kluft ^[8] ; Carine,Beysen ^[9] ; Claire,Emson ^[5] ; Alain J,van Gool ^[5] ; Roel,Goldschmeding ^[3] ; Reinout,Stoop ^[10] ; Ivana,Bobeldijk-Pastorova ^[2] ; Scott M,Turner ^[1] ; Guido,Hanauer ^[1] ; Roeland,Hanemaaijer ^[5]

作者单位： Department of Metabolic Health Research, TNO, Leiden, The Netherlands. ^[1] University Medical Center Utrecht, Utrecht, The Netherlands. ^[2] Department of Microbiology and Systems Biology, TNO, Zeist, The Netherlands. ^[3] Department of Pathology, Amsterdam University Medical Center, Amsterdam, The Netherlands. ^[4] Kinemed, Inc, Emeryville, California. ^[5] Takeda Pharmaceutical Company, Kanagawa, Japan. ^[6] BaseClear B.V., Leiden, The Netherlands. ^[7] Seventh Wave, Maryland Heights, Missouri. ^[8] Good Biomarker Sciences B.V., Leiden, The Netherlands. ^[9] Radboud University Medical Center, Nijmegen, The Netherlands. ^[10]

关键词 ALT, alanine aminotransferase AST, aspartate aminotransferase DEG, differentially expressed genes Diagnosis ECM, extracellular matrix HFD, high-fat diet IPA, Ingenuity Pathway Analysis LDLr-/-, low-density lipoprotein receptor knock out Liver Disease Metabolic Syndrome NAFLD, nonalcoholic fatty liver disease NASH, nonalcoholic steatohepatitis Systems Biology THBS1, thrombospontin-1

DOI 10.1016/j.jcmgh.2017.10.001

PMID 29276754

发布时间 2023-11-12

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Cellular and molecular gastroenterology and hepatology

2018年5卷1期

83-98.e10页

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Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model.

Cellular and molecular gastroenterology and hepatology

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Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model.

Cellular and molecular gastroenterology and hepatology

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Cellular and molecular gastroenterology and hepatology

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