Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation.

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第一作者： Chenglai,Fu

第一单位： From the Solomon H. Snyder Department of Neuroscience (C.F., R.T., A.C.C., T.R., P.G., I.A.B., F.R., R.X., J.Y.C., J.X., A.M.S., S.H.S.), Department of Pharmacology and Molecular Sciences (R.-J.L., S.H.S.), Institute for Cell Engineering (G.L.S.), McKusick-Nathans Institute of Genetic Medicine (G.L.S.), Department of Pediatrics (G.L.S.), Department of Medicine (G.L.S.), Department of Oncology (G.L.S.), Department of Radiation Oncology (G.L.S.), Department of Biological Chemistry (G.L.S.), and Department of Psychiatry and Behavioral Sciences (S.H.S.), Johns Hopkins University School of Medicine, Baltimore, MD.

作者： Chenglai,Fu ^[1] ; Richa,Tyagi ^[1] ; Alfred C,Chin ^[1] ; Tomas,Rojas ^[1] ; Ruo-Jing,Li ^[1] ; Prasun,Guha ^[1] ; Isaac A,Bernstein ^[1] ; Feng,Rao ^[1] ; Risheng,Xu ^[1] ; Jiyoung Y,Cha ^[1] ; Jing,Xu ^[1] ; Adele M,Snowman ^[1] ; Gregg L,Semenza ^[1] ; Solomon H,Snyder ^[2]

作者单位： From the Solomon H. Snyder Department of Neuroscience (C.F., R.T., A.C.C., T.R., P.G., I.A.B., F.R., R.X., J.Y.C., J.X., A.M.S., S.H.S.), Department of Pharmacology and Molecular Sciences (R.-J.L., S.H.S.), Institute for Cell Engineering (G.L.S.), McKusick-Nathans Institute of Genetic Medicine (G.L.S.), Department of Pediatrics (G.L.S.), Department of Medicine (G.L.S.), Department of Oncology (G.L.S.), Department of Radiation Oncology (G.L.S.), Department of Biological Chemistry (G.L.S.), and Department of Psychiatry and Behavioral Sciences (S.H.S.), Johns Hopkins University School of Medicine, Baltimore, MD. ^[1] From the Solomon H. Snyder Department of Neuroscience (C.F., R.T., A.C.C., T.R., P.G., I.A.B., F.R., R.X., J.Y.C., J.X., A.M.S., S.H.S.), Department of Pharmacology and Molecular Sciences (R.-J.L., S.H.S.), Institute for Cell Engineering (G.L.S.), McKusick-Nathans Institute of Genetic Medicine (G.L.S.), Department of Pediatrics (G.L.S.), Department of Medicine (G.L.S.), Department of Oncology (G.L.S.), Department of Radiation Oncology (G.L.S.), Department of Biological Chemistry (G.L.S.), and Department of Psychiatry and Behavioral Sciences (S.H.S.), Johns Hopkins University School of Medicine, Baltimore, MD. ssnyder@jhmi.edu. ^[2]

关键词 Egln1 protein blood–brain barrier hydroxylation inositol phosphates vascular endothelial growth factor A von Hippel-Lindau protein