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Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees.

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第一作者: Goo,Jun
第一单位: Department of Biostatistics, University of Michigan, Ann Arbor, MI 48105; goo.jun@uth.tmc.edu.;Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48105.;Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77225.
作者: Goo,Jun [1] ; Alisa,Manning [2] ; Marcio,Almeida [3] ; Matthew,Zawistowski [4] ; Andrew R,Wood [5] ; Tanya M,Teslovich [6] ; Christian,Fuchsberger [7] ; Shuang,Feng [4] ; Pablo,Cingolani [8] ; Kyle J,Gaulton [9] ; Thomas,Dyer [3] ; Thomas W,Blackwell [4] ; Han,Chen [10] ; Peter S,Chines [11] ; Sungkyoung,Choi [12] ; Claire,Churchhouse [2] ; Pierre,Fontanillas [2] ; Ryan,King [13] ; SungYoung,Lee [14] ; Stephen E,Lincoln [15] ; Vasily,Trubetskoy [13] ; Mark,DePristo [2] ; Tasha,Fingerlin [16] ; Robert,Grossman [13] ; Jason,Grundstad [13] ; Alison,Heath [13] ; Jayoun,Kim [17] ; Young Jin,Kim [18] ; Jason,Laramie [19] ; Jaehoon,Lee [17] ; Heng,Li [2] ; Xuanyao,Liu [20] ; Oren,Livne [13] ; Adam E,Locke [4] ; Julian,Maller [21] ; Alexander,Mazur [8] ; Andrew P,Morris [22] ; Toni I,Pollin [23] ; Derek,Ragona [13] ; David,Reich [24] ; Manuel A,Rivas [9] ; Laura J,Scott [4] ; Xueling,Sim [25] ; Rick G,Tearle [19] ; Yik Ying,Teo [26] ; Amy L,Williams [2] ; Sebastian,Zöllner [4] ; Joanne E,Curran [3] ; Juan,Peralta [3] ; Beena,Akolkar [27] ; Graeme I,Bell [28] ; Noël P,Burtt [2] ; Nancy J,Cox [29] ; Jose C,Florez [30] ; Craig L,Hanis [31] ; Catherine,McKeon [27] ; Karen L,Mohlke [32] ; Mark,Seielstad [33] ; James G,Wilson [34] ; Gil,Atzmon [35] ; Jennifer E,Below [36] ; Josée,Dupuis [37] ; Dan L,Nicolae [13] ; Donna,Lehman [38] ; Taesung,Park [17] ; Sungho,Won [39] ; Robert,Sladek [40] ; David,Altshuler [41] ; Mark I,McCarthy [42] ; Ravindranath,Duggirala [3] ; Michael,Boehnke [4] ; Timothy M,Frayling [5] ; Gonçalo R,Abecasis [4] ; John,Blangero [3]
作者单位: Department of Biostatistics, University of Michigan, Ann Arbor, MI 48105; goo.jun@uth.tmc.edu.;Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48105.;Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77225. [1] Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142. [2] South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville and Edinburg, TX 78520. [3] Department of Biostatistics, University of Michigan, Ann Arbor, MI 48105.;Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48105. [4] Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, United Kingdom. [5] Department of Biostatistics, University of Michigan, Ann Arbor, MI 48105.;Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48105.;Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591. [6] Department of Biostatistics, University of Michigan, Ann Arbor, MI 48105.;Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48105.;Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck, 39100 Bolzano, Italy. [7] Génome Québec Innovation Centre, McGill University, Montreal, QC H3A 0E9, Canada. [8] Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom. [9] Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77225.;Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118.;Center for Precision Health, School of Public Health and School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030. [10] Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892. [11] The Research Institute of Basic Sciences, Seoul National University, Seoul 08826, Republic of Korea. [12] Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, IL 60637. [13] Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul 08826, Republic of Korea. [14] Complete Genomics, Mountain View, CA 95134.;Invitae, San Francisco, CA 94103. [15] Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO 80045. [16] Department of Statistics, Seoul National University, Seoul 08826, Republic of Korea. [17] Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul 08826, Republic of Korea.;Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do 28159, Republic of Korea. [18] Complete Genomics, Mountain View, CA 95134. [19] Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore 117549. [20] Clinical Research Centre, Centre for Molecular Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom. [21] Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.;Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, United Kingdom. [22] Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.;Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201.;Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201. [23] Department of Genetics, Harvard Medical School, Boston, MA 02115. [24] Department of Biostatistics, University of Michigan, Ann Arbor, MI 48105.;Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48105.;Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore 117549. [25] Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore 117549.;Life Sciences Institute, National University of Singapore, Singapore 117549.;Department of Statistics and Applied Probability, National University of Singapore, Singapore 117549. [26] National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Bethesda, MD 20892. [27] Department of Medicine, The University of Chicago, Chicago, IL 60637.;Department of Human Genetics, The University of Chicago, Chicago, IL 60637. [28] Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, IL 60637.;Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN 37332. [29] Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142.;Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.;Department of Medicine, Harvard Medical School, Boston, MA.;Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114. [30] Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77225. [31] Department of Genetics, University of North Carolina, Chapel Hill, NC 27599. [32] Department of Laboratory Medicine, University of California, San Francisco, CA 94143.;Institute for Human Genetics, University of California, San Francisco, CA 94143.;Blood Systems Research Institute, San Francisco, CA 94118. [33] Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216. [34] Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461.;Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461.;Department of Natural Science, University of Haifa, 3498838 Haifa, Israel. [35] Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN 37332. [36] Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118.;National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA 01702. [37] Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229. [38] School of Public Health, Seoul National University, Seoul 08826, Republic of Korea. [39] Génome Québec Innovation Centre, McGill University, Montreal, QC H3A 0E9, Canada.;Department of Human Genetics, McGill University, Montreal, QC H3A 0G1, Canada.;Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada. [40] Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142.;Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, United Kingdom.;Department of Medicine, Harvard Medical School, Boston, MA.;Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, MA 02115.;Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142. [41] Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.;Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, United Kingdom.;Oxford National Institute for Health Research Biomedical Research Centre, Oxford University Hospitals Trust, Oxford OX4 2PG, United Kingdom. [42]
DOI 10.1073/pnas.1705859115
PMID 29279374
发布时间 2021-04-06
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Proceedings of the National Academy of Sciences of the United States of America

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