New metformin derivative HL156A prevents oral cancer progression by inhibiting the insulin-like growth factor/AKT/mammalian target of rapamycin pathways.
第一作者:
Thuy Giang,Lam
第一单位:
Department of Pathology, College of Dentistry, Chosun University, Gwangju, South Korea.
作者:
主题词
动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);细胞存活(Cell Survival);疾病恶化(Disease Progression);剂量效应关系, 药物(Dose-Response Relationship, Drug);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);胍类(Guanidines);人类(Humans);小鼠(Mice);口腔肿瘤(Mouth Neoplasms);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);吡咯烷类(Pyrrolidines);信号传导(Signal Transduction);生长调节素类(Somatomedins);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1111/cas.13482
PMID
29285837
发布时间
2022-03-30
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Cancer science
699-709页
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