换一批Novel click modifiable thioquinazolinones as anti-inflammatory agents: Design, synthesis, biological evaluation and docking study.
第一作者：
Ghandoura,Moussa
第一单位：
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.
作者：
医学主题词
动物(Animals);消炎药, 非甾类(Anti-Inflammatory Agents, Non-Steroidal);花生四烯酸盐15-脂氧合酶(Arachidonate 15-Lipoxygenase);细胞分化(Cell Differentiation);链接化学(Click Chemistry);环氧化酶1(Cyclooxygenase 1);环氧化酶2(Cyclooxygenase 2);环加氧酶抑制药(Cyclooxygenase Inhibitors);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物设计(Drug Design);女(雌)性(Female);人类(Humans);脂氧合酶抑制剂(Lipoxygenase Inhibitors);巨噬细胞(Macrophages);分子结构(Molecular Structure);喹唑啉酮类(Quinazolinones);大鼠(Rats);大鼠, Wistar(Rats, Wistar);构效关系(Structure-Activity Relationship);巯基化合物(Sulfhydryl Compounds);肿瘤细胞, 培养的(Tumor Cells, Cultured)
DOI
10.1016/j.ejmech.2017.12.065
PMID
29289887
发布时间
2018-03-02
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