Transcriptomics-guided bottom-up and top-down venomics of neonate and adult specimens of the arboreal rear-fanged Brown Treesnake, Boiga irregularis, from Guam.

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作者： Davinia,Pla ^[1] ; Daniel,Petras ^[2] ; Anthony J,Saviola ^[3] ; Cassandra M,Modahl ^[4] ; Libia,Sanz ^[1] ; Alicia,Pérez ^[1] ; Elena,Juárez ^[1] ; Seth,Frietze ^[4] ; Pieter C,Dorrestein ^[2] ; Stephen P,Mackessy ^[5] ; Juan J,Calvete ^[6]

作者单位： Laboratorio de Venómica Estructural y Funcional, Consejo Superior de Investigaciones Científicas, Valencia, Spain. ^[1] University of California San Diego, Skaggs School of Pharmacy & Pharmaceutical Sciences, 9500 Gilman Dr, La Jolla, CA 92093, USA. ^[2] Laboratorio de Venómica Estructural y Funcional, Consejo Superior de Investigaciones Científicas, Valencia, Spain; School of Biological Sciences, University of Northern Colorado, 501 20th Street, CB 92, Greeley, CO 80639, USA. ^[3] School of Biological Sciences, University of Northern Colorado, 501 20th Street, CB 92, Greeley, CO 80639, USA. ^[4] School of Biological Sciences, University of Northern Colorado, 501 20th Street, CB 92, Greeley, CO 80639, USA. Electronic address: stephen.mackessy@unco.edu. ^[5] Laboratorio de Venómica Estructural y Funcional, Consejo Superior de Investigaciones Científicas, Valencia, Spain. Electronic address: jcalvete@ibv.csic.es. ^[6]

关键词 Boiga irregularis from Guam Brown Treesnake Ontogenetic shift in venom composition Rear-fanged snake venomics Three-finger toxins Top-down snake venom proteomics Venom gland transcriptome Venom phenotypes