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Time resolved amplified FRET identifies protein kinase B activation state as a marker for poor prognosis in clear cell renal cell carcinoma.

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第一作者： James,Miles

第一单位： Cell Biophysics Laboratory, Ikerbasque, Basque Foundation for Science, FASTBASE SOLUTIONS Ltd, Research Centre for Experimental Marine Biology and Biotechnology (PiE) & Biofísika Institute (UPV/EHU, CSIC), University of the Basque Country, Spain.;Department of Pharmacy and Pharmacology, University of Bath, UK.;Department of Pathology, Cruces University Hospital, Biocruces Research Institute, University of the Basque Country (UPV/EHU), Barakaldo, Spain.

作者： James,Miles ^[1] ; Christopher J,Applebee ^[2] ; Pierre,Leboucher ^[3] ; Sonia,Lopez-Fernandez ^[2] ; Dae-Jin,Lee ^[4] ; Rosa,Guarch ^[5] ; Stephen,Ward ^[6] ; Peter J,Parker ^[7] ; Jose I,López ^[8] ; Banafshé,Larijani ^[2]

作者单位： Cell Biophysics Laboratory, Ikerbasque, Basque Foundation for Science, FASTBASE SOLUTIONS Ltd, Research Centre for Experimental Marine Biology and Biotechnology (PiE) & Biofísika Institute (UPV/EHU, CSIC), University of the Basque Country, Spain.;Department of Pharmacy and Pharmacology, University of Bath, UK.;Department of Pathology, Cruces University Hospital, Biocruces Research Institute, University of the Basque Country (UPV/EHU), Barakaldo, Spain. ^[1] Cell Biophysics Laboratory, Ikerbasque, Basque Foundation for Science, FASTBASE SOLUTIONS Ltd, Research Centre for Experimental Marine Biology and Biotechnology (PiE) & Biofísika Institute (UPV/EHU, CSIC), University of the Basque Country, Spain. ^[2] Institut du Cerveau et de la Moelle épinière, Hôpital de la Pitié-Salpêtrière, Paris, France. ^[3] Basque Centre for Applied Mathematics, Bilbao, Bizkaia, Spain. ^[4] Department of Pathology B, Complejo Hospitalario de Navarra, Pamplona, Spain. ^[5] Department of Pharmacy and Pharmacology, University of Bath, UK. ^[6] Protein Phosphorylation Laboratory, The Francis Crick Institute, London, UK and Division of Cancer Studies, King's College London, London, UK. ^[7] Department of Pathology, Cruces University Hospital, Biocruces Research Institute, University of the Basque Country (UPV/EHU), Barakaldo, Spain. ^[8]

关键词 Amplified FRET Biomarker activation Clear cell renal cell carcinoma Fret-FLIM Prognosis Protein kinase B (PKB/Akt)

DOI 10.1016/j.bbacli.2017.10.002

PMID 29296589

发布时间 2022-03-11

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2017年8卷

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Time resolved amplified FRET identifies protein kinase B activation state as a marker for poor prognosis in clear cell renal cell carcinoma.

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Time resolved amplified FRET identifies protein kinase B activation state as a marker for poor prognosis in clear cell renal cell carcinoma.

BBA clinical

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BBA clinical

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