Intracranial Aneurysm-Associated Single-Nucleotide Polymorphisms Alter Regulatory DNA in the Human Circle of Willis.

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作者： Melanie D,Laarman ^[1] ; Marit W,Vermunt ^[1] ; Rachel,Kleinloog ^[1] ; Jelkje J,de Boer-Bergsma ^[1] ; Netherlands,Brain Bank ^[1] ; Gabriël J E,Rinkel ^[1] ; Menno P,Creyghton ^[1] ; Michal,Mokry ^[1] ; Jeroen,Bakkers ^[1] ; Ynte M,Ruigrok ^[2]

作者单位： From the Department of Neurology and Neurosurgery (M.D.L., R.K., G.J.E., Y.M.R.), Hubrecht Institute-KNAW, and Division of Heart and Lungs, Department of Medical Physiology (J.B.), University Medical Center Utrecht, the Netherlands (M.D.L., M.W.V., M.P.C., J.B.); Department of Genetics, University Medical Center Groningen, University of Groningen, the Netherlands (J.J.d.B.-B.); Netherlands Institute for Neuroscience, Amsterdam (N.B.B.); and Division of Pediatrics, Wilhelmina Children's Hospital, Utrecht, the Netherlands (M.M.). ^[1] From the Department of Neurology and Neurosurgery (M.D.L., R.K., G.J.E., Y.M.R.), Hubrecht Institute-KNAW, and Division of Heart and Lungs, Department of Medical Physiology (J.B.), University Medical Center Utrecht, the Netherlands (M.D.L., M.W.V., M.P.C., J.B.); Department of Genetics, University Medical Center Groningen, University of Groningen, the Netherlands (J.J.d.B.-B.); Netherlands Institute for Neuroscience, Amsterdam (N.B.B.); and Division of Pediatrics, Wilhelmina Children's Hospital, Utrecht, the Netherlands (M.M.). ij.m.ruigrok@umcutrecht.nl. ^[2]

关键词 circle of Willis computational biology epigenomics gene expression intracranial aneurysm polymorphism, single nucleotide subarachnoid hemorrhage