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Elevated <i>HLA-A</i> expression impairs HIV control through inhibition of NKG2A-expressing cells.

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第一作者: Veron,Ramsuran
第一单位: Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.;Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.;KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.;Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.
作者单位: Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.;Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.;KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.;Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa. [1] Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.;Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.;Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.;Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. [2] Department of Oncological Sciences, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. [3] Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA. [4] Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA. [5] AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA. [6] School of Life Sciences, École Polytechnique Fédérale de Lausanne, and Swiss Institute of Bioinformatics, Lausanne, Switzerland. [7] Department of Medicine University of California, San Francisco, CA 94143, USA. [8] Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA. [9] Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA. [10] Division of Infectious Diseases, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. [11] U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. [12] Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA. [13] Department of Medicine University of California, San Francisco, CA 94143, USA.;Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA.;San Francisco Department of Public Health, HIV Research Section, San Francisco, CA 94102, USA. [14] Vanderbilt University School of Medicine, Nashville, TN 37232, USA. [15] Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.;African Health Research Institute, Durban, South Africa.;HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.;Max Planck Institute for Infection Biology, Berlin, Germany. [16] African Health Research Institute, Durban, South Africa.;Department of Paediatrics, University of Oxford, Oxford, UK. [17] Departments of Structural Biology and Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA. [18] Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.;African Health Research Institute, Durban, South Africa.;Institute for Medical and Engineering Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. [19] Microsoft Research, Redmond, WA 98052, USA. [20] Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA. carringm@mail.nih.gov.;Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA. [21]
DOI 10.1126/science.aam8825
PMID 29302013
发布时间 2024-07-16
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