Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations.

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作者： Ilaria,Prada ^[1] ; Martina,Gabrielli ^[1] ; Elena,Turola ^[2] ; Alessia,Iorio ^[1] ; Giulia,D'Arrigo ^[3] ; Roberta,Parolisi ^[4] ; Mariacristina,De Luca ^[5] ; Marco,Pacifici ^[5] ; Mattia,Bastoni ^[6] ; Marta,Lombardi ^[7] ; Giuseppe,Legname ^[3] ; Dan,Cojoc ^[8] ; Annalisa,Buffo ^[4] ; Roberto,Furlan ^[6] ; Francesca,Peruzzi ^[5] ; Claudia,Verderio ^[9]

作者单位： CNR Institute of Neuroscience, via Vanvitelli 32, 20129, Milan, Italy. ^[1] Gastroenterology Unit, Department of Internal Medicine, University of Modena and Reggio Emilia, 41124, Modena, Italy. ^[2] Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), via Bonomea 265, 34136, Trieste, Italy. ^[3] Department of Neuroscience Rita Levi-Montalcini and Neuroscience Institute Cavalieri Ottolenghi, University of Turin, 10126, Turin, Italy. ^[4] LSU Health Sciences Center School of Medicine and Stanley S. Scott Cancer Center, New Orleans, USA. ^[5] Clinical Neuroimmunology Unit, Department of Neuroscience, Institute for Experimental Neurology, San Raffaele Scientific Institute, via Olgettina 58, 20132, Milan, Italy. ^[6] IRCCS Humanitas, via Manzoni 56, 20089, Rozzano, Italy. ^[7] CNR-Institute of Materials, Area Science Park, 34149, Trieste, Basovizza, Italy. ^[8] CNR Institute of Neuroscience, via Vanvitelli 32, 20129, Milan, Italy. c.verderio@in.cnr.it. ^[9] IRCCS Humanitas, via Manzoni 56, 20089, Rozzano, Italy. c.verderio@in.cnr.it. ^[10]

关键词 Cognitive symptoms Extracellular vesicles Microglia Multiple sclerosis miRNAs