ERK inhibition promotes neuroectodermal precursor commitment by blocking self-renewal and primitive streak formation of the epiblast.

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作者： Yang,Yu ^[1] ; Xiaoxiao,Wang ^[2] ; Xiaoxin,Zhang ^[1] ; Yanhua,Zhai ^[2] ; Xukun,Lu ^[1] ; Haixia,Ma ^[1] ; Kai,Zhu ^[1] ; Tongbiao,Zhao ^[2] ; Jianwei,Jiao ^[1] ; Zhen-Ao,Zhao ^[2] ; Lei,Li ^[1]

作者单位： State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing, 100101, China. ^[1] University of Chinese Academy of Sciences, Beijing, 100049, China. ^[2] State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing, 100101, China. zhaozhenao@suda.edu.cn. ^[3] Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, 708 Renmin Rd, Suzhou, Jiangsu, 215007, China. zhaozhenao@suda.edu.cn. ^[4] State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing, 100101, China. lil@ioz.ac.cn. ^[5] University of Chinese Academy of Sciences, Beijing, 100049, China. lil@ioz.ac.cn. ^[6]

关键词 Embryonic stem cells Epiblast stem cells Extracellular signal-regulated protein kinase Neural differentiation PD0325901