Disrupting the 'Warburg effect' re-routes cancer cells to OXPHOS offering a vulnerability point via 'ferroptosis'-induced cell death.

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作者： Maša,Ždralević ^[1] ; Milica,Vučetić ^[2] ; Boutaina,Daher ^[2] ; Ibtissam,Marchiq ^[1] ; Scott K,Parks ^[2] ; Jacques,Pouysségur ^[3]

作者单位： Université Côte d'Azur, Institute for Research on Cancer and Aging (IRCAN), CNRS, INSERM, Centre A. Lacassagne, 33 avenue de Valombrose, Nice, France. ^[1] Medical Biology Department, Centre Scientifique de Monaco (CSM), Monaco. ^[2] Université Côte d'Azur, Institute for Research on Cancer and Aging (IRCAN), CNRS, INSERM, Centre A. Lacassagne, 33 avenue de Valombrose, Nice, France; Medical Biology Department, Centre Scientifique de Monaco (CSM), Monaco. Electronic address: pouysseg@unice.fr. ^[3]

关键词 Cancer Cystine transporter GPI Glycolysis LDH isoforms Lipid peroxidation MCT MonoCarboxylate transporters OXPHOS Pentose phosphate pathway ROS Warburg effect xCT

主题词动物(Animals);细胞死亡(Cell Death);细胞系, 肿瘤(Cell Line, Tumor);人类(Humans);乳酸脱氢酶类(Lactate Dehydrogenases);乳酸(Lactic Acid);氧化性应激(Oxidative Stress)

DOI 10.1016/j.jbior.2017.12.002

PMID 29306548

发布时间 2019-10-10

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