Late-occurring and Long-circulating Metabolites of GABAAα2,3 Receptor Modulator AZD7325 Involving Metabolic Cyclization and Aromatization: Relevance to MIST Analysis and Application for Patient Compliance.-论文-万方医学网

第一作者： Chungang,Gu

第一单位： DMPK, IMED Oncology, AstraZeneca, Waltham, Massachusetts (C.G); Early Chemical Development, IMED Pharmaceutical Sciences, AstraZeneca, Mölndal, Sweden (M.A., C.S.E); Medicinal Chemistry, IMED Respiratory Inflammation and Autoimmunity, AstraZeneca, Mölndal, Sweden (R.J.L.); and Legacy R&D at Wilmington, AstraZeneca, Wilmington, Delaware (C.G., C.S.E., P.D., J.E.H., B.T.D., G.C., M.A.S., M.C., M.S.) chuck.gu@biogen.com.

作者： Chungang,Gu ^[1] ; Markus,Artelsmair ^[2] ; Charles S,Elmore ^[2] ; Richard J,Lewis ^[2] ; Patty,Davis ^[2] ; James E,Hall ^[2] ; Bruce T,Dembofsky ^[2] ; Greg,Christoph ^[2] ; Mark A,Smith ^[2] ; Marc,Chapdelaine ^[2] ; Maria,Sunzel ^[2]

作者单位： DMPK, IMED Oncology, AstraZeneca, Waltham, Massachusetts (C.G); Early Chemical Development, IMED Pharmaceutical Sciences, AstraZeneca, Mölndal, Sweden (M.A., C.S.E); Medicinal Chemistry, IMED Respiratory Inflammation and Autoimmunity, AstraZeneca, Mölndal, Sweden (R.J.L.); and Legacy R&D at Wilmington, AstraZeneca, Wilmington, Delaware (C.G., C.S.E., P.D., J.E.H., B.T.D., G.C., M.A.S., M.C., M.S.) chuck.gu@biogen.com. ^[1] DMPK, IMED Oncology, AstraZeneca, Waltham, Massachusetts (C.G); Early Chemical Development, IMED Pharmaceutical Sciences, AstraZeneca, Mölndal, Sweden (M.A., C.S.E); Medicinal Chemistry, IMED Respiratory Inflammation and Autoimmunity, AstraZeneca, Mölndal, Sweden (R.J.L.); and Legacy R&D at Wilmington, AstraZeneca, Wilmington, Delaware (C.G., C.S.E., P.D., J.E.H., B.T.D., G.C., M.A.S., M.C., M.S.). ^[2]

主题词青少年(Adolescent);成年人(Adult);老年人(Aged);动物(Animals);环化(Cyclization);狗(Dogs);双盲法(Double-Blind Method);女(雌)性(Female);杂环化合物, 2环(Heterocyclic Compounds, 2-Ring);人类(Humans);羟基化(Hydroxylation);男(雄)性(Male);小鼠(Mice);微粒体, 肝(Microsomes, Liver);中年人(Middle Aged);病人依从(Patient Compliance);大鼠(Rats);大鼠, Wistar(Rats, Wistar);受体, GABA-A(Receptors, GABA-A);青年人(Young Adult)

DOI 10.1124/dmd.117.078873

PMID 29311137

发布时间 2025-02-12

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Late-occurring and Long-circulating Metabolites of GABA<sub>A</sub><i><sub>α</sub></i><sub>2,3</sub> Receptor Modulator AZD7325 Involving Metabolic Cyclization and Aromatization: Relevance to MIST Analysis and Application for Patient Compliance.

Drug metabolism and disposition

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Late-occurring and Long-circulating Metabolites of GABA<sub>A</sub><i><sub>α</sub></i><sub>2,3</sub> Receptor Modulator AZD7325 Involving Metabolic Cyclization and Aromatization: Relevance to MIST Analysis and Application for Patient Compliance.

Drug metabolism and disposition

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Drug metabolism and disposition

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