Improved diagnostic stratification of digitised Barrett's oesophagus biopsies by p53 immunohistochemical staining.

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作者： Myrtle J,van der Wel ^[1] ; Lucas C,Duits ^[2] ; Roos E,Pouw ^[2] ; Cornelis A,Seldenrijk ^[2] ; G J A,Offerhaus ^[3] ; Mike,Visser ^[4] ; Fiebo J,Ten Kate ^[5] ; Katharina,Biermann ^[4] ; Lodewijk A A,Brosens ^[6] ; Michael,Doukas ^[4] ; Clement,Huysentruyt ^[6] ; Arend,Karrenbeld ^[7] ; Gursah,Kats-Ugurlu ^[8] ; Jaap S,van der Laan ^[8] ; G Ineke,van Lijnschoten ^[9] ; Freek C P,Moll ^[7] ; Ariadne H A G,Ooms ^[10] ; Hans,van der Valk ^[11] ; Jan G,Tijssen ^[11] ; Jacques J,Bergman ^[12] ; Sybren L,Meijer ^[2]

作者单位： Department of Pathology, Academic Medical Centre, Amsterdam, The Netherlands. ^[1] Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands. ^[2] Department of Pathology, Pathology-DNA, St Antonius Hospital, Nieuwegein, The Netherlands. ^[3] Department of Pathology, University Medical Centre, Utrecht, The Netherlands. ^[4] Department of Pathology, Symbiant BV, Alkmaar, The Netherlands. ^[5] Department of Pathology, Erasmus Medical Centre, Rotterdam, The Netherlands. ^[6] Department of Pathology, Stichting PAMM, Eindhoven, The Netherlands. ^[7] Department of Pathology, Academic Medical Centre, Groningen, The Netherlands. ^[8] Department of Pathology, Haga Hospital, The Hague, The Netherlands. ^[9] Department of Pathology, Isala Clinics, Zwolle, The Netherlands. ^[10] Department of Pathology, St Fransiscus Vlietland Gasthuis, Pathan BV, Rotterdam, The Netherlands. ^[11] Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands. ^[12]

关键词 Barrett's oesophagus interobserver agreement low-grade dysplasia p53 immunohistochemistry review panel whole-slide imaging

主题词 Barrett食管(Barrett Esophagus);活组织检查(Biopsy);人类(Humans);图像解释, 计算机辅助(Image Interpretation, Computer-Assisted);免疫组织化学(Immunohistochemistry);观察者偏差(Observer Variation);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53)

DOI 10.1111/his.13462

PMID 29314176

发布时间 2018-09-06

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