Analysis of viral diversity for vaccine target discovery.

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作者： Asif M,Khan ^[1] ; Yongli,Hu ^[2] ; Olivo,Miotto ^[3] ; Natascha M,Thevasagayam ^[4] ; Rashmi,Sukumaran ^[5] ; Hadia Syahirah,Abd Raman ^[3] ; Vladimir,Brusic ^[3] ; Tin Wee,Tan ^[6] ; J,Thomas August ^[7]

作者单位： Centre for Bioinformatics, School of Data Sciences, Perdana University, Jalan MAEPS Perdana, Serdang, Selangor Darul Ehsan, 43400, Malaysia. asif@perdanauniversity.edu.my. ^[1] Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD, 21205, USA. asif@perdanauniversity.edu.my. ^[2] Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore, 117597, Singapore. ^[3] Centre for Genomics and Global Health, University of Oxford, Oxford, UK. ^[4] Mahidol-Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Rajthevee, Bangkok, Thailand. ^[5] Centre for Bioinformatics, School of Data Sciences, Perdana University, Jalan MAEPS Perdana, Serdang, Selangor Darul Ehsan, 43400, Malaysia. ^[6] Menzies Health Institute Queensland, Griffith University, Parklands Dr, Southport, 4215, QLD, Australia. ^[7] Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD, 21205, USA. ^[8]

关键词 Bioinformatics Database Reverse vaccinology Target discovery Tools Vaccine design Viral diversity

主题词氨基酸序列(Amino Acid Sequence);计算生物学(Computational Biology);保守序列(Conserved Sequence);遗传变异(Genetic Variation);种特异性(Species Specificity);病毒蛋白质类(Viral Proteins);病毒疫苗(Viral Vaccines)

DOI 10.1186/s12920-017-0301-2

PMID 29322922

发布时间 2024-03-13

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准确一般字义偏差语意偏离译文作用小提交