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Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients.

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第一单位: Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.;Systems Biology of Signal Transduction, German Cancer Research Center, Heidelberg, Germany.
作者单位: Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.;Systems Biology of Signal Transduction, German Cancer Research Center, Heidelberg, Germany. [1] Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany. [2] Center for Modeling and Simulation in the Biosciences (BIOMS), University of Heidelberg, Heidelberg, Germany.;Life Sciences Research Unit, University of Luxembourg, Luxembourg, Luxembourg. [3] Medical Research Centre, University of Heidelberg, Mannheim, Germany. [4] Center for Modeling and Simulation in the Biosciences (BIOMS), University of Heidelberg, Heidelberg, Germany.;Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany. [5] Institute of Computational Biology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany. [6] Department of Cancer Biology & Genetics, Memorial Sloan Kettering Cancer Center, New York, New York. [7] Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany. [8] Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. [9] Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.;Translational Lung Research Center Heidelberg (TLRC-H), member of the German Center for Lung Research (DZL), Heidelberg, Germany. [10] Translational Lung Research Center Heidelberg (TLRC-H), member of the German Center for Lung Research (DZL), Heidelberg, Germany.;Translational Research Unit, Thoraxklinik at the University Hospital Heidelberg, Heidelberg, Germany. [11] Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.;Helmholtz University Group "Cell Plasticity and Epigenetic Remodeling," German Cancer Research Center, Heidelberg, Germany. [12] Center for Modeling and Simulation in the Biosciences (BIOMS), University of Heidelberg, Heidelberg, Germany.;Center for Computational and Theoretical Biology, University of Würzburg, Würzburg, Germany. [13] Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. kai.breuhahn@med.uni-heidelberg.de. [14]
DOI 10.1158/1541-7786.MCR-17-0334
PMID 29330288
发布时间 2022-04-08
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Molecular cancer research : MCR

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