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Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer.

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作者单位: Institute of Oncology Research, Oncology Institute of Southern Switzerland, Università della Svizzera Italiana, Bellinzona, Switzerland. [1] Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland. [2] Computational Structural Biology, Institute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland. [3] Imaging Facility, Institute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland. [4] Division of Signal Transduction, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. [5] Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy. [6] Nano-inspired Biomedicine Lab, Institute of Paediatric Research-Città della Speranza, Padova, Italy. [7] Surgical Clinic, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, Padova, Italy. [8] Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy. [9] CNR Institute of Neuroscience and Department of Biomedical Sciences, University of Padova, Padova, Italy. [10] Molecular Oncology Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain. [11] Biomedical Research Institute I+12, University Hospital 12 de Octubre, Madrid, Spain. [12] Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain. [13] Roegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway. [14] Drug Development Unit, Division of Cancer Therapeutics and Division of Clinical Studies, Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, UK. [15] CIC bioGUNE, Bizkaia Technology Park, Bizkaia, Spain. [16] Ikerbasque, Basque Foundation for Science, Bilbao, Spain. [17] Biochemistry and Molecular Biology Department, University of the Basque Country, Bilbao, Spain. [18] Institute of Oncology Research, Oncology Institute of Southern Switzerland, Università della Svizzera Italiana, Bellinzona, Switzerland. andrea.alimonti@ior.iosi.ch. [19] Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland. andrea.alimonti@ior.iosi.ch. [20] Department of Medicine, Venetian Institute of Molecular Medicine, University of Padova, Padova, Italy. andrea.alimonti@ior.iosi.ch. [21]
DOI 10.1038/s41588-017-0026-3
PMID 29335542
发布时间 2024-06-10
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