MUC16 C terminal-induced secretion of tumor-derived IL-6 contributes to tumor-associated Treg enrichment in pancreatic cancer.

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作者： Kun,Fan ^[1] ; Chao,Yang ^[1] ; Zhiyao,Fan ^[1] ; Qiuyi,Huang ^[1] ; Yiyin,Zhang ^[1] ; He,Cheng ^[1] ; Kaizhou,Jin ^[1] ; Yu,Lu ^[1] ; Zhengshi,Wang ^[1] ; Guopei,Luo ^[1] ; Xianjun,Yu ^[2] ; Chen,Liu ^[3]

作者单位： Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, PR China; Department of Oncology, Shanghai Medical College, Fudan University, PR China; Shanghai Pancreatic Cancer Institute, Shanghai, 200032, PR China; Pancreatic Cancer Institute, Fudan University, Shanghai, 200032, PR China. ^[1] Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, PR China; Department of Oncology, Shanghai Medical College, Fudan University, PR China; Shanghai Pancreatic Cancer Institute, Shanghai, 200032, PR China; Pancreatic Cancer Institute, Fudan University, Shanghai, 200032, PR China. Electronic address: yuxianjun@fudanpci.org. ^[2] Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, PR China; Department of Oncology, Shanghai Medical College, Fudan University, PR China; Shanghai Pancreatic Cancer Institute, Shanghai, 200032, PR China; Pancreatic Cancer Institute, Fudan University, Shanghai, 200032, PR China. Electronic address: liuchen@fudanpci.org. ^[3]

关键词 IL-6 JAK2/STAT3 MUC16c Pancreatic cancer Tumor-associated Treg