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Identification of novel quinazolinedione derivatives as RORγt inverse agonist.

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第一作者： Yoshiyuki,Fukase

第一单位： Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd, 26-1, Muraokahigashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.

作者： Yoshiyuki,Fukase ^[1] ; Ayumu,Sato ^[2] ; Yoshihide,Tomata ^[1] ; Atsuko,Ochida ^[1] ; Mitsunori,Kono ^[1] ; Kazuko,Yonemori ^[1] ; Keiko,Koga ^[1] ; Toshitake,Okui ^[1] ; Masashi,Yamasaki ^[1] ; Yasushi,Fujitani ^[1] ; Hideyuki,Nakagawa ^[1] ; Ryoukichi,Koyama ^[1] ; Masaharu,Nakayama ^[1] ; Robert,Skene ^[3] ; Bi-Ching,Sang ^[3] ; Isaac,Hoffman ^[3] ; Junya,Shirai ^[1] ; Satoshi,Yamamoto ^[1]

作者单位： Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd, 26-1, Muraokahigashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan. ^[1] Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd, 26-1, Muraokahigashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan. Electronic address: ayumu.sato@takeda.com. ^[2] Takeda California, Inc., 10410 Science Center Drive, San Diego, CA 92121, United States. ^[3]

关键词 EAE model IL-17 Inverse agonist Quinazolinedione RORγt (retinoic acid receptor-related orphan receptor gamma t)Th17