One-step synthesis of an <sup>18</sup>F-labeled boron-derived methionine analog: a substitute for <sup>11</sup>C-methionine?

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作者： Zhen,Liu ^[1] ; Emily B,Ehlerding ^[2] ; Weibo,Cai ^[3] ; Xiaoli,Lan ^[4]

作者单位： Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. ^[1] Hubei Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. ^[2] Department of Medical Physics, University of Wisconsin - Madison, Madison, WI, USA. ^[3] Department of Medical Physics, University of Wisconsin - Madison, Madison, WI, USA. wcai@uwhealth.org. ^[4] Department of Radiology, University of Wisconsin - Madison, 1111 Highland Avenue, Madison, WI, 53705, USA. wcai@uwhealth.org. ^[5] Carbone Cancer Center, University of Wisconsin - Madison, Madison, WI, 53705, USA. wcai@uwhealth.org. ^[6] Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. LXL730724@hotmail.com. ^[7] Hubei Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. LXL730724@hotmail.com. ^[8]

关键词 11C-Methionine (11C-MET)18F-B-MET Amino acid transporter Boramino acid Cancer Positron emission tomography (PET)

主题词硼(Boron);脑肿瘤(Brain Neoplasms);碳放射性同位素(Carbon Radioisotopes);神经胶质瘤(Glioma);人类(Humans);甲硫氨酸(Methionine);正电子发射断层显像术(Positron-Emission Tomography)

DOI 10.1007/s00259-017-3927-6

PMID 29349488

发布时间 2019-04-01

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